- Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE. Hwang, D.Y., Seo, S., Kim, Y., Kim, C., Shim, S., Jee, S., Lee, S., Sin, J., Cho, J., Kang, B., Jang, I., Cho, J. Int. J. Mol. Med. (2007)