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Ito, Y. et al.

Ito, Motoo, Yoshida, Iovanna, Takamura, Miya, Kuma, Miyauchi,

Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma.

BACKGROUND: Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress- induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated. MATERIALS AND METHODS: TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma. RESULTS: Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression. CONCLUSION: Decreased expression of TP53INP1 is involved in breast carcinoma progression.[1]

References

Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma. Ito, Y., Motoo, Y., Yoshida, H., Iovanna, J.L., Takamura, Y., Miya, A., Kuma, K., Miyauchi, A. Anticancer Res. (2006) [Pubmed]

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