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Gene Review

TP53INP1  -  tumor protein p53 inducible nuclear protein 1

Homo sapiens

Synonyms: DKFZp434M1317, FLJ22139, P53DINP1, SIP, Stress-induced protein, ...
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Disease relevance of TP53INP1


Psychiatry related information on TP53INP1


High impact information on TP53INP1


Chemical compound and disease context of TP53INP1


Biological context of TP53INP1


Anatomical context of TP53INP1


Associations of TP53INP1 with chemical compounds


Enzymatic interactions of TP53INP1

  • Furthermore, the protein complex interacting with p53DINP1 was shown to phosphorylate Ser46 of p53 [22].

Regulatory relationships of TP53INP1


Other interactions of TP53INP1


Analytical, diagnostic and therapeutic context of TP53INP1


  1. Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer. Jiang, P.H., Motoo, Y., Garcia, S., Iovanna, J.L., Pébusque, M.J., Sawabu, N. World J. Gastroenterol. (2006) [Pubmed]
  2. TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Tomasini, R., Seux, M., Nowak, J., Bontemps, C., Carrier, A., Dagorn, J.C., Pébusque, M.J., Iovanna, J.L., Dusetti, N.J. Oncogene (2005) [Pubmed]
  3. Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma. Ito, Y., Motoo, Y., Yoshida, H., Iovanna, J.L., Takamura, Y., Miya, A., Kuma, K., Miyauchi, A. Anticancer Res. (2006) [Pubmed]
  4. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. Naka, K., Tachibana, A., Ikeda, K., Motoyama, N. J. Biol. Chem. (2004) [Pubmed]
  5. Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Rau, V., DeCola, J.P., Fanselow, M.S. Neuroscience and biobehavioral reviews. (2005) [Pubmed]
  6. Stress-induced hallucinations. Klemperer, F. The British journal of psychiatry : the journal of mental science. (1992) [Pubmed]
  7. Stress-induced and sympathetically-mediated electrocardiographic and circulatory variations in the primary hyperkinetic heart syndrome. Guazzi, M., Fiorentini, C., Polese, A., Magrini, F., Olivari, M.T. Cardiovasc. Res. (1975) [Pubmed]
  8. Cardiovascular reactivity to psychological stress may enhance subsequent pain sensitivity. Caceres, C., Burns, J.W. Pain (1997) [Pubmed]
  9. Suppressed aggression accelerates early development of essential hypertension. Perini, C., Müller, F.B., Bühler, F.R. J. Hypertens. (1991) [Pubmed]
  10. Exercise and the immune system: regulation, integration, and adaptation. Pedersen, B.K., Hoffman-Goetz, L. Physiol. Rev. (2000) [Pubmed]
  11. Activation of Glucosidase via Stress-Induced Polymerization Rapidly Increases Active Pools of Abscisic Acid. Lee, K.H., Piao, H.L., Kim, H.Y., Choi, S.M., Jiang, F., Hartung, W., Hwang, I., Kwak, J.M., Lee, I.J., Hwang, I. Cell (2006) [Pubmed]
  12. Stress-induced immunomodulation: implications for infectious diseases? Glaser, R., Rabin, B., Chesney, M., Cohen, S., Natelson, B. JAMA (1999) [Pubmed]
  13. Stress-induced cortisol release in hypothalamic hypoadrenalism. Glass, A.R., Smith, C.E. JAMA (1979) [Pubmed]
  14. Low-fat diet and regular, supervised physical exercise in patients with symptomatic coronary artery disease: reduction of stress-induced myocardial ischemia. Schuler, G., Schlierf, G., Wirth, A., Mautner, H.P., Scheurlen, H., Thumm, M., Roth, H., Schwarz, F., Kohlmeier, M., Mehmel, H.C. Circulation (1988) [Pubmed]
  15. Stress-induced gastroduodenal lesions and total parenteral nutrition in critically ill patients: frequency, complications, and the value of prophylactic treatment. A prospective, randomized study. Ruiz-Santana, S., Ortiz, E., Gonzalez, B., Bolaños, J., Ruiz-Santana, A.J., Manzano, J.L. Crit. Care Med. (1991) [Pubmed]
  16. The sympathetic nervous system in essential hypertension. Tuck, M.L. Am. Heart J. (1986) [Pubmed]
  17. Stress-induced left ventricular dysfunction in silent and symptomatic myocardial ischemia during dobutamine stress test. Elhendy, A., Geleijnse, M.L., Roelandt, J.R., Cornel, J.H., van Domburg, R.T., Fioretti, P.M. Am. J. Cardiol. (1995) [Pubmed]
  18. Stress-induced hemodynamic and hemostatic changes in patients with systemic hypertension: effect of verapamil. Gebara, O.C., Jimenez, A.H., McKenna, C., Mittleman, M.A., Xu, P., Lipinska, I., Muller, J.E., Tofler, G.H. Clinical cardiology. (1996) [Pubmed]
  19. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. Tomasini, R., Samir, A.A., Carrier, A., Isnardon, D., Cecchinelli, B., Soddu, S., Malissen, B., Dagorn, J.C., Iovanna, J.L., Dusetti, N.J. J. Biol. Chem. (2003) [Pubmed]
  20. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Hershko, T., Chaussepied, M., Oren, M., Ginsberg, D. Cell Death Differ. (2005) [Pubmed]
  21. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. Nowak, J., Tomasini, R., Mattei, M.G., Azizi Samir, L.A., Dagorn, J.C., Dusetti, N., Iovanna, J.L., Pébusque, M.J. Cytogenet. Genome Res. (2002) [Pubmed]
  22. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Okamura, S., Arakawa, H., Tanaka, T., Nakanishi, H., Ng, C.C., Taya, Y., Monden, M., Nakamura, Y. Mol. Cell (2001) [Pubmed]
  23. Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Karawajew, L., Rhein, P., Czerwony, G., Ludwig, W.D. Blood (2005) [Pubmed]
  24. Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies. Pacak, K., Palkovits, M., Kopin, I.J., Goldstein, D.S. Frontiers in neuroendocrinology. (1995) [Pubmed]
  25. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Czéh, B., Michaelis, T., Watanabe, T., Frahm, J., de Biurrun, G., van Kampen, M., Bartolomucci, A., Fuchs, E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells. Jiang, P.H., Motoo, Y., Sawabu, N., Minamoto, T. World J. Gastroenterol. (2006) [Pubmed]
  27. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Toussaint, O., Medrano, E.E., von Zglinicki , T. Exp. Gerontol. (2000) [Pubmed]
  28. Release of mast cell mediators into the jejunum by cold pain stress in humans. Santos, J., Saperas, E., Nogueiras, C., Mourelle, M., Antolín, M., Cadahia, A., Malagelada, J.R. Gastroenterology (1998) [Pubmed]
  29. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Sinha, R., Garcia, M., Paliwal, P., Kreek, M.J., Rounsaville, B.J. Arch. Gen. Psychiatry (2006) [Pubmed]
  30. Decreased epinephrine in familial alcoholism. Initial findings. Swartz, C.M., Drews, V., Cadoret, R. Arch. Gen. Psychiatry (1987) [Pubmed]
  31. CREB and NF-kappaB Transcription Factors Regulate Sensitivity to Excitotoxic and Oxidative Stress Induced Neuronal Cell Death. Zou, J., Crews, F. Cell. Mol. Neurobiol. (2006) [Pubmed]
  32. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. Knebel, A., Haydon, C.E., Morrice, N., Cohen, P. Biochem. J. (2002) [Pubmed]
  33. Changes of adrenomedullin and its receptor components mRNAs expression in the brain stem and hypothalamus-pituitary-adrenal axis of stress-induced hypertensive rats. Li, X., Li, L., Shen, L.L., Qian, Y., Cao, Y.X., Zhu, D.N. Sheng li xue bao [Acta physiologica Sinica]. (2004) [Pubmed]
  34. Evaluation of hypothalamic-pituitary-adrenal axis in amenorrhoeic women with insulin-dependent diabetes. la Marca, A., Morgante, G., De Leo, V. Hum. Reprod. (1999) [Pubmed]
  35. Stress-induced release of HSC70 from human tumors. Barreto, A., Gonzalez, J.M., Kabingu, E., Asea, A., Fiorentino, S. Cell. Immunol. (2003) [Pubmed]
  36. Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis. Ramírez, R., Carracedo, J., Soriano, S., Jiménez, R., Martín-Malo, A., Rodríguez, M., Blasco, M., Aljama, P. Am. J. Kidney Dis. (2005) [Pubmed]
  37. Stress-induced analgesia: adaptive pain suppression. Amit, Z., Galina, Z.H. Physiol. Rev. (1986) [Pubmed]
  38. Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease. Schuler, G., Hambrecht, R., Schlierf, G., Niebauer, J., Hauer, K., Neumann, J., Hoberg, E., Drinkmann, A., Bacher, F., Grunze, M. Circulation (1992) [Pubmed]
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