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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3.

CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells. We have reported that CDX2 promotes tumorigenicity in a subset of human colorectal cancer cell lines. Here, we present evidence that CDX2 negatively regulates the well-documented growth inhibitor insulin-like growth factor binding protein-3 (IGFBP-3). Specifically, CDX2 binds to the IGFBP-3 gene promoter and can repress IGFBP-3 transcription, protein expression and secretion. Furthermore, inhibition of IGFBP-3 partially rescues the decreased anchorage-independent growth phenotype observed in CDX2 knockout cells. These data demonstrate for the first time that (1) CDX2 can function as a transcriptional repressor, and (2) one mechanism by which CDX2 promotes anchorage-independent growth is by transcriptional repression of IGFBP-3.[1]

References

  1. CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3. Chun, S.Y., Chen, F., Washburn, J.G., MacDonald, J.W., Innes, K.L., Zhao, R., Cruz-Correa, M.R., Dang, L.H., Dang, D.T. Oncogene (2007) [Pubmed]
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