Gene Review:
CDX2 - caudal type homeobox 2
Homo sapiens
Synonyms:
CDX-3, CDX2/AS, CDX3, Caudal-type homeobox protein 2, Homeobox protein CDX-2
Sakai,
Lord,
DeMeester,
Yuasa,
Cheng,
Iacobuzio-Donahue,
Holscher,
Danenberg,
Takizawa,
Klimstra,
Nagasaki,
Levi,
Takeshi Kuwata,
Murer,
Tot,
Tani,
Brabender,
Nakachi,
Akiyama,
Koike,
Capitanio,
Mieko Hamano,
Makoto Saegusa,
Jan,
Chen,
Iwai,
Miki Hashimura,
Adsay,
Chen,
Ohkura,
Wickramasinghe,
Sugihara,
Brambilla,
Liu,
Merati,
Yeh,
Schneider,
Tseng,
Cavazza,
Sarkar,
Hruban,
DeMeester,
Marchioni,
Yoji Wani,
Basturk,
Migaldi,
Isao Okayasu,
Rossi,
Chiu,
Imai,
Losi,
Natali,
Nakajima,
- Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003)
- Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. Hansel, D.E., Maitra, A., Lin, J.W., Goggins, M., Argani, P., Yeo, C.J., Piantadosi, S., Leach, S.D., Biankin, A.V. J. Clin. Oncol. (2005)
- PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Sakai, H., Eishi, Y., Li, X.L., Akiyama, Y., Miyake, S., Takizawa, T., Konishi, N., Tatematsu, M., Koike, M., Yuasa, Y. Gut (2004)
- Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. Qualtrough, D., Hinoi, T., Fearon, E., Paraskeva, C. Gut (2002)
- Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. Rossi, G., Murer, B., Cavazza, A., Losi, L., Natali, P., Marchioni, A., Migaldi, M., Capitanio, G., Brambilla, E. Am. J. Surg. Pathol. (2004)
- Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Baba, Y., Nosho, K., Shima, K., Freed, E., Irahara, N., Philips, J., Meyerhardt, J.A., Hornick, J.L., Shivdasani, R.A., Fuchs, C.S., Ogino, S. Clin. Cancer Res. (2009)
- Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Yuasa, Y., Nagasaki, H., Akiyama, Y., Sakai, H., Nakajima, T., Ohkura, Y., Takizawa, T., Koike, M., Tani, M., Iwai, T., Sugihara, K., Imai, K., Nakachi, K. Carcinogenesis (2005)
- The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Uitterlinden, A.G., Ralston, S.H., Brandi, M.L., Carey, A.H., Grinberg, D., Langdahl, B.L., Lips, P., Lorenc, R., Obermayer-Pietsch, B., Reeve, J., Reid, D.M., Amidei, A., Bassiti, A., Bustamante, M., Husted, L.B., Diez-Perez, A., Dobnig, H., Dunning, A.M., Enjuanes, A., Fahrleitner-Pammer, A., Fang, Y., Karczmarewicz, E., Kruk, M., van Leeuwen, J.P., Mavilia, C., van Meurs, J.B., Mangion, J., McGuigan, F.E., Pols, H.A., Renner, W., Rivadeneira, F., van Schoor, N.M., Scollen, S., Sherlock, R.E., Ioannidis, J.P. Ann. Intern. Med. (2006)
- Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Debruyne, P.R., Witek, M., Gong, L., Birbe, R., Chervoneva, I., Jin, T., Domon-Cell, C., Palazzo, J.P., Freund, J.N., Li, P., Pitari, G.M., Schulz, S., Waldman, S.A. Gastroenterology (2006)
- CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. Hinoi, T., Gesina, G., Akyol, A., Kuick, R., Hanash, S., Giordano, T.J., Gruber, S.B., Fearon, E.R. Gastroenterology (2005)
- Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. Eda, A., Osawa, H., Yanaka, I., Satoh, K., Mutoh, H., Kihira, K., Sugano, K. J. Gastroenterol. (2002)
- Value of CDX2, villin, and alpha-methylacyl coenzyme A racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Suh, N., Yang, X.J., Tretiakova, M.S., Humphrey, P.A., Wang, H.L. Mod. Pathol. (2005)
- Expression of the intestinal transcription factor CDX2 in carcinoid tumors is a marker of midgut origin. Jaffee, I.M., Rahmani, M., Singhal, M.G., Younes, M. Arch. Pathol. Lab. Med. (2006)
- A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis. Sakamoto, H., Mutoh, H., Ido, K., Satoh, K., Hayakawa, H., Sugano, K. Hum. Pathol. (2007)
- SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.N., Clevers, H., Jay, P. J. Cell Biol. (2004)
- CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Bai, Y.Q., Miyake, S., Iwai, T., Yuasa, Y. Oncogene (2003)
- Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Yamamoto, H., Bai, Y.Q., Yuasa, Y. Biochem. Biophys. Res. Commun. (2003)
- Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Song, B.L., Wang, C.H., Yao, X.M., Yang, L., Zhang, W.J., Wang, Z.Z., Zhao, X.N., Yang, J.B., Qi, W., Yang, X.Y., Inoue, K., Lin, Z.X., Zhang, H.Z., Kodama, T., Chang, C.C., Liu, Y.K., Chang, T.Y., Li, B.L. Biochem. J. (2006)
- Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Chase, A., Reiter, A., Burci, L., Cazzaniga, G., Biondi, A., Pickard, J., Roberts, I.A., Goldman, J.M., Cross, N.C. Blood (1999)
- Expression of homeodomain protein CDX2 in gallbladder carcinomas. Wu, X.S., Akiyama, Y., Igari, T., Kawamura, T., Hiranuma, S., Shibata, T., Tsuruta, K., Koike, M., Arii, S., Yuasa, Y. J. Cancer Res. Clin. Oncol. (2005)
- Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. Lord, R.V., Brabender, J., Wickramasinghe, K., DeMeester, S.R., Holscher, A., Schneider, P.M., Danenberg, P.V., DeMeester, T.R. Surgery (2005)
- The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. Jette, C., Peterson, P.W., Sandoval, I.T., Manos, E.J., Hadley, E., Ireland, C.M., Jones, D.A. J. Biol. Chem. (2004)
- Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells. Boulanger, J., Vézina, A., Mongrain, S., Boudreau, F., Perreault, N., Auclair, B.A., Lainé, J., Asselin, C., Rivard, N. J. Biol. Chem. (2005)
- CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. La Rosa, S., Rigoli, E., Uccella, S., Chiaravalli, A.M., Capella, C. Virchows Arch. (2004)
- CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. Ko, S., Chu, K.M., Luk, J.M., Wong, B.W., Yuen, S.T., Leung, S.Y., Wong, J. J. Pathol. (2005)
- CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3. Chun, S.Y., Chen, F., Washburn, J.G., MacDonald, J.W., Innes, K.L., Zhao, R., Cruz-Correa, M.R., Dang, L.H., Dang, D.T. Oncogene (2007)
- Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Dang, D.T., Mahatan, C.S., Dang, L.H., Agboola, I.A., Yang, V.W. Oncogene (2001)
- CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. da Costa, L.T., He, T.C., Yu, J., Sparks, A.B., Morin, P.J., Polyak, K., Laken, S., Vogelstein, B., Kinzler, K.W. Oncogene (1999)
- Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2. Gregory, P.A., Lewinsky, R.H., Gardner-Stephen, D.A., Mackenzie, P.I. Mol. Pharmacol. (2004)
- A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas. Saegusa, M., Hashimura, M., Kuwata, T., Hamano, M., Wani, Y., Okayasu, I. Carcinogenesis (2007)
- Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions. Yeh, T.S., Tseng, J.H., Chen, T.C., Liu, N.J., Chiu, C.T., Jan, Y.Y., Chen, M.F. Hepatology (2005)
- Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Adsay, N.V., Merati, K., Basturk, O., Iacobuzio-Donahue, C., Levi, E., Cheng, J.D., Sarkar, F.H., Hruban, R.H., Klimstra, D.S. Am. J. Surg. Pathol. (2004)
- Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Ishikawa, A., Sasaki, M., Ohira, S., Ohta, T., Oda, K., Nimura, Y., Chen, M.F., Jan, Y.Y., Yeh, T.S., Nakanuma, Y. Lab. Invest. (2004)
- Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia. Rawat, V.P., Cusan, M., Deshpande, A., Hiddemann, W., Quintanilla-Martinez, L., Humphries, R.K., Bohlander, S.K., Feuring-Buske, M., Buske, C. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Identifying colorectal metastases in liver biopsies: the novel CDX2 antibody is less specific than the cytokeratin 20+/7- phenotype. Tot, T. Med. Sci. Monit. (2004)