Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Behbahani, H. et al.

Homira Behbahani, Lilian Walther-Jallow, Elin Klareskog, Linda Baum, Audrey L. French, Bruce K. Patterson, Patricia Garcia, Anna-Lena Spetz, Alan Landay, Jan Andersson,

Proinflammatory and type 1 cytokine expression in cervical mucosa during HIV-1 and human papillomavirus infection.

Suppression of immune activation and increased inflammation are prevalent during viral infection. To investigate the role of inflammation in HIV transmission, we studied the infectious and inflammatory milieu in cervical mucosa from HIV-1- and human papillomavirus (HPV)-coinfected and HPV-monoinfected women. The numbers of cytokine-, chemokine-, and p24-expressing cells were determined using in situ imaging analysis and intracellular staining of p24 antigen. Significantly higher expression of the proinflammatory cytokines, interleukin (IL)-1alpha/beta, was seen in cervical tissue from HIV/HPV-coinfected as compared with HPV-monoinfected tissues, whereas IL-2- and interferon (IFN)-gamma-expressing cells were higher in HPV-monoinfected tissues. IL-10 was low in both groups, whereas IL-4 was significantly higher in HPV-monoinfected and HIV/HPV-coinfected tissues than in HIV/HPV-negative controls. RANTES and macrophage inflammatory protein (MIP)-1beta but not MIP-1alpha were significantly higher in the genital tract of HIV/HPV-coinfected as compared with HPV-monoinfected individuals and controls. HIV/HPV-coinfected tissues had a higher level of human leukocyte antigen D-related (HLA-DR)-expressing dendritic cells (DCs). There was a positive correlation between the number of CD4(+) and CD8(+) T cells as well as CD1a, IL-1alpha, and RANTES expression and p24 antigen-expressing cells in the HIV/HPV-coinfected tissues. These findings suggest the persistence of immune activation and inflammation in the genital tract of women with HPV monoinfection and in HIV-infected women coinfected with HPV.[1]

References

Proinflammatory and type 1 cytokine expression in cervical mucosa during HIV-1 and human papillomavirus infection. Behbahani, H., Walther-Jallow, L., Klareskog, E., Baum, L., French, A.L., Patterson, B.K., Garcia, P., Spetz, A.L., Landay, A., Andersson, J. J. Acquir. Immune Defic. Syndr. (2007) [Pubmed]

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