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Fayon, M. et al.

Fayon, Tayara, Germain, Choukroun, Dumas De La Roque, Chêne, Breilh, Marthan, Demarquez,

Efficacy and Tolerance of High-Dose Inhaled Ipratropium Bromide vs. Terbutaline in Intubated Premature Human Neonates.

Background: There is insufficient data to reliably assess the benefit of bronchodilators in ventilated premature neonates. Objectives: To compare the efficacy/tolerance of inhaled ipratropium bromide (IB) vs. terbutaline (T) and to describe factors associated with their efficacy. Methods: A cross-over randomized controlled double-blind trial including intubated neonates with respiratory distress syndrome. Two puffs of IB or T were administered at 0, 20, 40 min. Passive respiratory system resistance (Rrs) and compliance (Crs) were measured at 0, 20, 40, 60 min. A positive response was defined as a >2 individual coefficients of variation decrease in Rrs or increase in Crs. Results: Twenty-one infants (gestational age (mean +/- SD): 27.3 +/- 1.6 weeks; birth weight: 947 +/- 250 g; postnatal age: 20 +/- 9 days) were included. At 60 min, no treatment effect for Rrs and Crs could be identified (cross-over analysis). Overall data (irrespective of order of administration) showed that after 6 puffs, the decrease in Rrs was greater in the IB vs. T group (-17.0 +/- 22.2% vs. -11.3 +/- 26.7%, respectively (NS)). Thirty-eight percent of infants responded to IB vs. 43% to T. However, in 19% of patients, decreased Crs was observed after 6 puffs of T. No marker of a positive or paradoxical response could be identified. Treatment was well-tolerated. Conclusion: High doses of bronchodilators are required in ventilated neonates, but the positive response rate was <50%. Their long-term benefit remains to be proven. Copyright (c) 2007 S. Karger AG, Basel.[1]

References

Efficacy and Tolerance of High-Dose Inhaled Ipratropium Bromide vs. Terbutaline in Intubated Premature Human Neonates. Fayon, M., Tayara, N., Germain, C., Choukroun, M.L., Dumas De La Roque, E., Chêne, G., Breilh, D., Marthan, R., Demarquez, J.L. Neonatology (2007) [Pubmed]

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