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Chemical Compound Review

Atrovent     [(1R,5R)-8-methyl-8-propan-2- yl-8...

Synonyms: Aerodose, Aerovent, Atronase, Ipravent, Apovent, ...
 
 
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Disease relevance of N-Isopropylatropine

 

Psychiatry related information on N-Isopropylatropine

  • After an extensive screening program, 5,887 participants have been randomized to one of three groups: usual care, intervention with smoking cessation and the use of a placebo inhaler, and intervention with smoking cessation and the use of ipratropium bromide [6].
  • RESULTS: Improvement in FEV1 and area under the FEV1 response-time curve from time 0 to 4 h (FEV1AUC0-4) was significantly greater for the combination of albuterol plus ipratropium than either agent alone on all test days [7].
 

High impact information on N-Isopropylatropine

 

Chemical compound and disease context of N-Isopropylatropine

 

Biological context of N-Isopropylatropine

 

Anatomical context of N-Isopropylatropine

  • Pulmonary effects of sulfur dioxide exposure and ipratropium bromide pretreatment in adults with nonallergic asthma [20].
  • Ipratropium bromide, two sprays (20 micrograms per spray) in each nasal cavity four times daily, for 3 weeks, produced a major reduction in nasal discharge severity and duration (p less than 0.00005 for daytime reduction in both) [21].
  • Unlike ipratropium bromide (100 nM), which dissociated so quickly that there was little difference in the [3H]NMS association, compared with vehicle-treated membranes, Ba 679 BR (1 nM) had a strong protective effect against [3H]NMS binding ( > 70%) that lasted for 90 min [22].
  • Like ipratropium bromide, Ba 679 BR showed no selectivity in its interactions with rat cerebrocortical M1 receptors (labeled with [3H]telenzepine) or heart M2 and salivary gland M3 receptors [labeled with [N-methyl-3H]scopolamine ([3H)] [22].
  • CONCLUSION: Low-dose ipratropium can decrease airway size by the initial, preferential blockade of neuronal M2 muscarinic receptors, whereas a larger dose of ipratropium blocks M3 muscarinic receptors on airway smooth muscle, resulting in bronchodilation [23].
 

Associations of N-Isopropylatropine with other chemical compounds

 

Gene context of N-Isopropylatropine

 

Analytical, diagnostic and therapeutic context of N-Isopropylatropine

References

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