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Chemical Compound Review

Brethine     5-[1-hydroxy-2-(tert- butylamino)ethyl]benz...

Synonyms: Bricanyl, Bricaril, Brethaire, Asthmasian, Brican, ...
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Disease relevance of terbutaline


Psychiatry related information on terbutaline


High impact information on terbutaline

  • We investigated whether tolerance develops to the protective effect of inhaled terbutaline on airway responsiveness to the bronchoconstrictors methacholine (which acts directly on airway smooth muscle) and AMP (which acts indirectly by stimulating the release of mediators from mast cells) during sustained treatment with terbutaline [10].
  • After seven days of treatment with terbutaline, the protective effect of terbutaline against methacholine decreased to 2.2 doubling doses (95 percent confidence interval, 1.3 to 3.0; P = 0.04), and that against AMP decreased even more, to 1.7 doubling doses (95 percent confidence interval, 1.1 to 2.4; P less than 0.001) [10].
  • To assess whether an extension tube between the aerosol source and the patient improves drug-inhalation therapy in children with acute bronchoconstriction, we treated 20 children under double-blind conditions with placebo or terbutaline delivered by a conventional aerosol or an aerosol with a tube spacer [11].
  • Both terbutaline treatments resulted in a significant increase in forced expiratory volume in one second, as compared with placebo (P less than 0.001), but treatment with the tube-spacer aerosol produced significantly more improvement than did treatment with the conventional aerosol (P less than 0.01) [11].
  • In 17 patients with moderate to severe asthma, we compared acute bronchodilator effects of the following drugs or drug combinations using a double-blind crossover design: terbutaline, 5; aminophyline 400; terbutaline, 5, plus aminophyline, 400; terbutaline, 2.5; aminophylline, 200; terbutaline, 2.5, plus aminophyline, 200 mg; and placebo [12].

Chemical compound and disease context of terbutaline


Biological context of terbutaline

  • During terbutaline therapy, heart rate, ejection fraction, and cardiac output increased significantly [1].
  • Patients taking formoterol had a longer time to their first severe asthma exacerbation (relative-risk ratio 0.55 [95% CI 0.34-0.89]), took fewer inhalations of study drug, and had larger increases in FEV1 (5%) and morning and evening peak expiratory flow (mean difference in increase 11 L/min and 8 L/min) than those taking terbutaline [18].
  • In normal rats, terbutaline administration (32 body wt) increased both cardiac output and portal tributary blood flow, thus mimicking hemodynamic changes in cirrhotic rats [19].
  • In cirrhotic rats, despite a significant increase in portal tributary blood flow (from 19.9 +/- 1.7 ml/min to 22.7 +/- 1.5 ml/min), terbutaline decreased portal pressure from 17.4 +/- 1.0 mm Hg to 15.0 +/- 0.8 mm Hg [19].
  • In vivo intravenous infusions of terbutaline (dose range 25 to 300 ng/kg body weight per min for 15 min) dose dependently increased heart rate and shortened the pre-ejection period and heart rate-corrected electromechanical systole (QS2) time [20].

Anatomical context of terbutaline


Associations of terbutaline with other chemical compounds


Gene context of terbutaline


Analytical, diagnostic and therapeutic context of terbutaline


  1. Terbutaline and maternal cardiac function. Wagner, J.M., Morton, M.J., Johnson, K.A., O'Grady, J.P., Speroff, L. JAMA (1981) [Pubmed]
  2. The effect of terbutaline on cardiac function in patients with stable chronic obstructive lung disease. Sunderrajan, E.V., Byron, W.A., McKenzie, W.N., Hurst, D.J., Allegro, M.M., Thakur, V.M., Holmes, R.A. JAMA (1983) [Pubmed]
  3. Ventricular tachycardia after terbutaline. Kinney, E.L., Trautlein, J.J., Harbaugh, C.V., Lambert, D., Zelis, R.F. JAMA (1978) [Pubmed]
  4. Angina pectoris associated with use of terbutaline for premature labor. Tye, K.H., Desser, K.B., Benchimol, A. JAMA (1980) [Pubmed]
  5. Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex. Rhodes, M.C., Seidler, F.J., Abdel-Rahman, A., Tate, C.A., Nyska, A., Rincavage, H.L., Slotkin, T.A. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  6. Changes in maternal serum aldosterone, potassium and prolactin levels during beta-receptor agonist treatment in third trimester pregnancies. Bremme, K., Eneroth, P., Hagenfeld, L., Hellgren, M. Horm. Metab. Res. (1982) [Pubmed]
  7. Symptomatology, pulmonary function and response, and T lymphocyte beta 2-receptors during smoking cessation in patients with chronic obstructive pulmonary disease. Leader, W.G., Wolf, K.M., Cooper, T.M., Chandler, M.H. Pharmacotherapy (1994) [Pubmed]
  8. Terbutaline sustained-release treatment during one week 5 mg b.i.d. compared to one week placebo: terbutaline plasma levels, c-AMP plasma levels, lung function and tremor measurement. van der Vet, A.P., Kreukniet, J., Drost, R.H., Maes, R.A., Fokkens, J.K., Hamelink, M.L. International journal of clinical pharmacology, therapy, and toxicology. (1987) [Pubmed]
  9. Effect of atropine and terbutaline on motor activity of the continent caecal reservoir for urine. Månsson, W., Hedlund, H., Andersson, K.E. British journal of urology. (1989) [Pubmed]
  10. Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma. O'Connor, B.J., Aikman, S.L., Barnes, P.J. N. Engl. J. Med. (1992) [Pubmed]
  11. Aerosol treatment of bronchoconstriction in children, with or without a tube spacer. Pedersen, S. N. Engl. J. Med. (1983) [Pubmed]
  12. Bronchodilator effects of terbutaline and aminophylline alone and in combination in asthmatic patients. Wolfe, J.D., Tashkin, D.P., Calvarese, B., Simmons, M. N. Engl. J. Med. (1978) [Pubmed]
  13. Treatment of the systemic capillary leak syndrome with terbutaline and theophylline. A case series. Tahirkheli, N.K., Greipp, P.R. Ann. Intern. Med. (1999) [Pubmed]
  14. Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice. Brandwein, S.R., Sipe, J.D., Cohen, A.S. Arthritis Rheum. (1994) [Pubmed]
  15. beta-adrenergic stimulation restores rat lung ability to clear edema in ventilator-associated lung injury. Saldías, F.J., Lecuona, E., Comellas, A.P., Ridge, K.M., Rutschman, D.H., Sznajder, J.I. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  16. Alanine and terbutaline in treatment of hypoglycemia in IDDM. Wiethop, B.V., Cryer, P.E. Diabetes Care (1993) [Pubmed]
  17. Acute effects of terbutaline and epinephrine on asthma. Double-blind crossover placebo study. Schwartz, H.J., Trautlein, J.J., Goldstein, A.R. J. Allergy Clin. Immunol. (1976) [Pubmed]
  18. Comparison of formoterol and terbutaline for as-needed treatment of asthma: a randomised trial. Tattersfield, A.E., Löfdahl, C.G., Postma, D.S., Eivindson, A., Schreurs, A.G., Rasidakis, A., Ekström, T. Lancet (2001) [Pubmed]
  19. Hemodynamic effects of terbutaline, a beta 2-adrenoceptor agonist, in conscious rats with secondary biliary cirrhosis. Poo, J.L., Braillon, A., Hadengue, A., Gaudin, C., Lebrec, D. Hepatology (1992) [Pubmed]
  20. Positive inotropic effects of the beta 2-adrenoceptor agonist terbutaline in the human heart: effects of long-term beta 1-adrenoceptor antagonist treatment. Schäfers, R.F., Adler, S., Daul, A., Zeitler, G., Vogelsang, M., Zerkowski, H.R., Brodde, O.E. J. Am. Coll. Cardiol. (1994) [Pubmed]
  21. Comparison of the acute cardiopulmonary effects of oral albuterol, metaproterenol, and terbutaline in asthmatics. Wolfe, J.D., Yamate, M., Biedermann, A.A., Chu, T.J. JAMA (1985) [Pubmed]
  22. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. Maisel, A.S., Knowlton, K.U., Fowler, P., Rearden, A., Ziegler, M.G., Motulsky, H.J., Insel, P.A., Michel, M.C. J. Clin. Invest. (1990) [Pubmed]
  23. Demonstration of an in vivo functional beta 3-adrenoceptor in man. Enocksson, S., Shimizu, M., Lönnqvist, F., Nordenström, J., Arner, P. J. Clin. Invest. (1995) [Pubmed]
  24. Effect of terbutaline, a beta 2-adrenoreceptor agonist, on gastric acid secretion and serum gastrin concentrations in humans. Thirlby, R.C., Richardson, C.T., Chew, P., Feldman, M. Gastroenterology (1988) [Pubmed]
  25. Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen. Brodde, O.E., Brinkmann, M., Schemuth, R., O'Hara, N., Daul, A. J. Clin. Invest. (1985) [Pubmed]
  26. Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma. Wong, C.S., Pavord, I.D., Williams, J., Britton, J.R., Tattersfield, A.E. Lancet (1990) [Pubmed]
  27. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Vathenen, A.S., Knox, A.J., Higgins, B.G., Britton, J.R., Tattersfield, A.E. Lancet (1988) [Pubmed]
  28. Role of beta 1-receptors and vagal tone in cardiac inotropic and chronotropic responses to a beta 2-agonist in humans. Levine, M.A., Leenen, F.H. Circulation (1989) [Pubmed]
  29. Modulation of interleukin-6 by beta2-adrenoceptor in endotoxin-stimulated renal macrophage cells. Nakamura, A., Johns, E.J., Imaizumi, A., Yanagawa, Y., Kohsaka, T. Kidney Int. (1999) [Pubmed]
  30. Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Deng, C., Moinat, M., Curtis, L., Nadakal, A., Preitner, F., Boss, O., Assimacopoulos-Jeannet, F., Seydoux, J., Giacobino, J.P. Endocrinology (1997) [Pubmed]
  31. Regulation of progestin biosynthetic enzymes in cultured rat granulosa cells: effects of prolactin, beta 2-adrenergic agonist, human chorionic gonadotropin and gonadotropin releasing hormone. Jones, P.B., Valk, C.A., Hsueh, A.J. Biol. Reprod. (1983) [Pubmed]
  32. Beta 2-adrenergic receptor agonist induces IL-18 production without IL-12 production. Takahashi, H.K., Iwagaki, H., Mori, S., Yoshino, T., Tanaka, N., Nishibori, M. J. Neuroimmunol. (2004) [Pubmed]
  33. The bronchodilator effects of aerosolized terbutaline. A controlled, double-blind study. Bachus, B.F., Snider, G.L. JAMA (1977) [Pubmed]
  34. Double-blind evaluation of nebulized cromolyn, terbutaline, and the combination for childhood asthma. Shapiro, G.G., Furukawa, C.T., Pierson, W.E., Sharpe, M.J., Menendez, R., Bierman, C.W. J. Allergy Clin. Immunol. (1988) [Pubmed]
  35. Extrapulmonary effects of terbutaline during prolonged administration. Bengtsson, B., Fagerstrom, P.O. Clin. Pharmacol. Ther. (1982) [Pubmed]
  36. Impaired tracheal mucus transport in allergic bronchoconstriction: effect of terbutaline pretreatment. Weissberger, D., Oliver, W., Abraham, W.M., Wanner, A. J. Allergy Clin. Immunol. (1981) [Pubmed]
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