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Oterino, A. et al.

A. Oterino, C. Ruiz-Alegría, J. Castillo, N. Valle, Y. Bravo, A. Cayón, A. Alonso, P. Tejera, N. Ruiz-Lavilla, P. Muñoz, J. Pascual,

GNAS1 T393C polymorphism is associated with migraine.

Migraineurs have an interictal sympathetic nervous system (SNS) hypofunctionality and hypersensitivity to adrenergic amines. The GNAS1 T393C polymorphism has been associated with a distinct SNS sensitivity in healthy subjects. We tested GNAS1 T393C variant in two independent sets of subjects. In the case-control subset, 365 migraine patients [194 with aura (MA)] vs. 347 healthy controls were studied. A significant excess of the CC genotype was found in migraneurs (31.2%) as opposed to controls (20.2%; P=0.003). Using a logistic regression model corrected for sex, the CC genotype conferred a general risk for migraine twice [odds ratio (OR) 1.79, 95% confidence interval (CI) 1.27-2.53; P=0.001] higher than CT/TT genotypes. Using parents from 117 migraine families, a marginally significant trend for association could be observed (P=0.025), but the transmission disequilibrium test for alleles maternally transmitted failed to demonstrate familial association. In this subgroup, CC genotype conferred a risk for migraine over twice (OR 2.20; 95% CI 1.14-4.40; P=0.019) higher than TT/TC genotypes. In conclusion, the GNAS1 T393C variant is associated with migraine, which suggests a genetic basis for its higher SNS sensitivity.[1]

References

GNAS1 T393C polymorphism is associated with migraine. Oterino, A., Ruiz-Alegría, C., Castillo, J., Valle, N., Bravo, Y., Cayón, A., Alonso, A., Tejera, P., Ruiz-Lavilla, N., Muñoz, P., Pascual, J. Cephalalgia (2007) [Pubmed]

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