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Quantification of brain tissue alterations in Fabry disease using diffusion-tensor imaging.

Central nervous system involvement is a major burden in Fabry disease. Conventional cranial magnetic resonance imaging (MRI) shows micro- and macroangiopathic changes such as severe and progressive white matter lesions (WMLs) at an early age on T2- and fluid-attenuated inversion recovery-weighted images, increased signal intensity in the pulvinar on T1-weighted MRI, as well as tortuosity and dilatation of the larger vessels (dolicho-ectasia). Using diffusion tensor imaging (DTI), a new structural MRI-technique that measures water diffusion characteristics, we showed marked brain tissue alterations in Fabry disease predominantly in the periventricular white matter. Even patients with few WMLs had significantly elevated brain tissue diffusivity. Conclusion: DTI is more sensitive in detecting brain tissue changes in Fabry disease than conventional MRI. DTI measurements could provide appropriate surrogate parameters with which to monitor the natural history of structural brain involvement and potential effects of therapy (such as enzyme replacement) in Fabry disease.[1]

References

  1. Quantification of brain tissue alterations in Fabry disease using diffusion-tensor imaging. Fellgiebel, A., Albrecht, J., Dellani, P.R., Schermuly, I., Stoeter, P., Müller, M.J. Acta paediatrica (Oslo, Norway : 1992). Supplement (2007) [Pubmed]
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