Disease relevance of Natural History

• Zidovudine and the natural history of the acquired immunodeficiency syndrome [1].
• We conclude that oral acyclovir given for four months markedly reduces but does not completely prevent recurrences of genital herpes and does not influence the long-term natural history of the disease [2].
• To determine the natural history of diabetes insipidus in children with histiocytosis, we measured the response of urinary arginine vasopressin to water deprivation every six months in 21 children who did not have diabetes insipidus and who had had histiocytosis for less than four years [3].
• DESIGN AND SETTING: A Monte-Carlo simulation based on a Markov model was used to simulate the natural history of prostate cancer using different starting ages, testing intervals, and PSA thresholds for prostate biopsy [4].
• To determine if hearing loss and ELSTs are a component of VHL, we examined prevalence, clinical presentation, and natural history of hearing loss and ELSTs in VHL [5].

Psychiatry related information on Natural History

• Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history [6].
• CONCLUSION: The effects of heroin on morphine glucuronidation are not shared by methadone or alcohol (two drugs that figure prominently in the natural history of heroin addiction) and do not appear to depend on the activation of MOR [7].
• Nine patients with congenital ocular motor apraxia (COMA) are presented and the natural history of this condition is considered [8].
• The clinical features, natural history and response to treatment were typical of the condition but the association with mental retardation, epilepsy and psychotic phenomena were unusual [9].
• Here we review the natural history and clinicobiological features of 113 NB cases managed uniformly in our institution in an attempt to characterize useful genetic markers to support the decision making of noncytotoxic versus cytotoxic approaches for each category of NB [10].

High impact information on Natural History

• This finding has important implications for family screening and provides direction for further investigation into the causes and natural history of dilated cardiomyopathy [11].
• The natural history of impaired glucose tolerance in the Pima Indians [12].
• Natural history of symptomatic partial ornithine transcarbamylase deficiency [13].
• The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease [14].
• In the course of natural history of autoimmune AD, the presence of adrenal cortex and/or steroid 21-hydroxylase autoantibodies identified patients at risk to develop AD [15].

Chemical compound and disease context of Natural History

• However, the role of estrogen in the natural history of DCIS is unknown [16].
• Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone [17].
• The data suggest that a course of treatment with cyclophosphamide known to influence the natural history of the nephrotic syndrome is not necessarily followed by a severe abnormality of sperm production; nevertheless, great caution is still required in the use of the drug [18].
• The natural history of Wolfram syndrome suggests that most patients will eventually develop most complications of this progressive, neurodegenerative disorder [19].
• Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy [20].

Biological context of Natural History

• The natural history and epidemiology of diabetic nephropathy. Implications for prevention and control [21].
• Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA [22].
• Epidemiology, classification, natural history, and genetics of epilepsy [23].
• The purpose of this study was to determine exercise tolerance and cardiac response to exercise for a large cohort of adult subjects with aortic stenosis, pulmonary stenosis, or ventricular septal defect participating in the Second Natural History Study of Congenital Heart Defects (NHS-2) [24].
• Systemic lupus erythematosus in three ethnic groups. XIX. Natural history of the accrual of the American College of Rheumatology criteria prior to the occurrence of criteria diagnosis [25].

Anatomical context of Natural History

• PURPOSE: To review evidence about thyroxine suppressive therapy in patients with thyroid nodules, including the clinical importance and natural history of nodules and the effects and potential side effects of thyroxine therapy [26].
• To clarify the natural history and management of patients with aberrant origin of a coronary artery from the aorta, we reviewed 18 patients whose right (RCA) or left (LCA) coronary artery arose aberrantly and passed between the aorta and right ventricular infundibulum [27].
• However, recent biopsy studies in humans have provided evidence that podocytes are functionally and structurally injured very early in the natural history of diabetic nephropathy [28].
• Applications of a computer simulation model of the natural history of CD4 T-cell number in HIV-infected individuals [29].
• AIMS: To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic surveillance of the duodenum is indicated [30].

Associations of Natural History with chemical compounds

• The natural history of estrogen-responsive breast cancers often involves a phenotypic change to an estrogen-unresponsive, more aggressive tumor [31].
• Digoxin has not been shown to affect the natural history of heart failure and should be reserved for patients who remain symptomatic after treatment with ACE inhibitors and diuretics [32].
• Longitudinal studies are required to establish the natural history of renal dysfunction following cadmium accumulation in industrial workers [33].
• Cocaine-packet ingestion. Diagnosis, management, and natural history [34].
• Natural history of valvular regurgitation 1 year after discontinuation of dexfenfluramine therapy. A randomized, double-blind, placebo-controlled trial [35].

Gene context of Natural History

• CONCLUSIONS: MLH1-associated colorectal cancer has a natural history different from that of common sporadic colorectal cancer [36].
• BACKGROUND: Hereditary breast cancer has been associated with mutations in the BRCA1 and BRCA2 genes and has a natural history different from sporadic breast cancer [37].
• Such a model will be critical for the understanding of the natural history of HD and for the testing of new therapeutic modalities [38].
• The International Fanconi Anemia Registry (IFAR), a prospectively collected database of FA patients, allows us the unique opportunity to analyze the natural history of this rare, clinically heterogeneous disorder in a large number of patients [39].
• Larger screening studies in more diverse populations are necessary to characterize the burden of disease and to follow those at risk (based on HFE or iron status measures) to establish the natural history of hemochromatosis [40].

Analytical, diagnostic and therapeutic context of Natural History

• Natural history of progression after PSA elevation following radical prostatectomy [41].
• Osmolality changes during hemodialysis. Natural history, clinical correlations, and influence of dialysate glucose and intravenous mannitol [42].
• The effects of nifedipine on the natural history of regional myocardial perfusion, the electrocardiogram, and enzyme release from the heart were dose related and cannot be generalized [43].
• Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history [44].
• Evolving data from several centers indicate that liver transplantation indeed prolongs survival in patients with PBC and PSC as compared with estimated survival using disease-specific risk scores based on the natural history of PBC and PSC [45].

References