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Gene Review

POU3F3  -  POU class 3 homeobox 3

Homo sapiens

Synonyms: BRN1, Brain-1, Brain-specific homeobox/POU domain protein 1, Brn-1, OTF-8, ...

Biological context of POU3F3


Associations of POU3F3 with chemical compounds

  • Antagonists were also identified of the related BRN1/DNA and BRN2/DNA transcription factor complexes indicating that a 1,4-disubstituted naphthalene may be a privileged scaffold for preparing screening libraries targeting this family of transcription factor complexes [2].


  1. Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2. Sumiyama, K., Washio-Watanabe, K., Ono, T., Yoshida, M.C., Hayakawa, T., Ueda, S. Mamm. Genome (1998) [Pubmed]
  2. Privileged scaffolds for blocking protein-protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX-PBX/DNA. Ji, T., Lee, M., Pruitt, S.C., Hangauer, D.G. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
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