Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Cundy, T. et al.

Tim Cundy, Greg Gamble, Leonie Neale, Rose Elder, Paul McPherson, Patrick Henley, Janet Rowan,

Differing causes of pregnancy loss in type 1 and type 2 diabetes.

OBJECTIVE: Women with type 2 and type 1 diabetes have differing risk factors for pregnancy loss. We compared the rates and causes of pregnancy loss in women with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS: We utilized prospectively collected data on all pregnancies in a 20-year period (1986-2005) from a single center with a high prevalence of type 2 diabetes. Pregnancy losses included terminations for medical reasons and deaths up to 1 month postpartum but not spontaneous pregnancy losses <20 weeks' gestation. RESULTS: There were 870 pregnancies in women with known diabetes (330 with type 1 and 540 with type 2 diabetes) and 325 in women with diabetes diagnosed in pregnancy but persisting postpartum (97% type 2 diabetes). The rate of pregnancy loss was similar in type 1 and type 2 diabetes (2.6 vs. 3.7%, P = 0.39), but the causes of pregnancy loss differed. In type 1 diabetes >75% were attributable to major congenital anomalies or prematurity; in type 2 diabetes >75% were attributable to stillbirth or chorioamnionitis (P = 0.017). Women with type 2 and type 1 diabetes had similar A1C at presentation and near term, but the former were older (P < 0.001) and more obese (P < 0.0001). CONCLUSIONS: There are significant differences in the main causes of pregnancy loss in women with type 1 and type 2 diabetes. The higher rates of stillbirth in women with type 2 diabetes, suggest that other features, such as obesity, contribute significantly to pregnancy losses.[1]

References

Differing causes of pregnancy loss in type 1 and type 2 diabetes. Cundy, T., Gamble, G., Neale, L., Elder, R., McPherson, P., Henley, P., Rowan, J. Diabetes. Care (2007) [Pubmed]

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