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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Profilin and profilin mRNA in the cerebellum of the developing rat.

Profilin and profilin mRNA concentrations were determined in the cerebellum of the developing rat. Profilin represented nearly 0.1% of total Triton-soluble protein both at birth and at the end of the developmental period. During brain maturation, the profilin concentration was regulated at the transcriptional level. A transient increase of profilin mRNA and profilin was observed at the end of the first postnatal week, a period of intense cell proliferation, neuritic outgrowth and synaptogenesis. We propose that profilin may act by forming, during the critical period of cerebellar development, a reserve pool of monomeric actin that can easily be mobilized in cell regions such as growth cones or synaptic junctions where filamentous actin is highly concentrated.[1]

References

  1. Profilin and profilin mRNA in the cerebellum of the developing rat. Léna, J.Y., Sri Widada, J., Ferraz, C., Liautard, J.P., Rabié, A., Faivre-Sarrailh, C. Neuroreport (1991) [Pubmed]
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