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Gene Review

Pfn1  -  profilin 1

Rattus norvegicus

Synonyms: Profilin I, Profilin-1
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Disease relevance of Pfn1


Psychiatry related information on Pfn1

  • We propose that profilin may act by forming, during the critical period of cerebellar development, a reserve pool of monomeric actin that can easily be mobilized in cell regions such as growth cones or synaptic junctions where filamentous actin is highly concentrated [2].

High impact information on Pfn1


Biological context of Pfn1


Anatomical context of Pfn1


Associations of Pfn1 with chemical compounds

  • Profilin and actin mRNA increased after acute and chronic treatments of carbon tetrachloride, which is associated with the increase of fibronectin, type-III and -IV collagen mRNA [11].
  • Profilin represented nearly 0.1% of total Triton-soluble protein both at birth and at the end of the developmental period [2].
  • The concentration of profilin mRNA decreased in dBcAMP-reactive astrocytes (-46%) [12].
  • Pretreatment with 1 microM BFA increased the PIP2 signal on profilin-1 x 54% after 15 mins, followed by a decline to subbasal levels after 60 mins [13].

Regulatory relationships of Pfn1

  • These studies identify a previously unrecognized oxysterol-binding protein-mediated mode of activation of STAT3 that controls the expression of the proatherogenic protein profilin-1 in response to 7-ketocholesterol and the diabetic milieu [14].

Other interactions of Pfn1


Analytical, diagnostic and therapeutic context of Pfn1


  1. Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. Tamura, M., Tanaka, H., Hirano, T., Ueta, Y., Higashi, K., Hirano, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  2. Profilin and profilin mRNA in the cerebellum of the developing rat. Léna, J.Y., Sri Widada, J., Ferraz, C., Liautard, J.P., Rabié, A., Faivre-Sarrailh, C. Neuroreport (1991) [Pubmed]
  3. Mechanism of actin polymerization in cellular ATP depletion. Atkinson, S.J., Hosford, M.A., Molitoris, B.A. J. Biol. Chem. (2004) [Pubmed]
  4. Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain. Hasegawa, H., Zinsser, S., Rhee, Y., Vik-Mo, E.O., Davanger, S., Hay, J.C. Mol. Biol. Cell (2003) [Pubmed]
  5. Polymerization of actin in RBL-2H3 cells can be triggered through either the IgE receptor or the adenosine receptor but different signaling pathways are used. Apgar, J.R. Mol. Biol. Cell (1994) [Pubmed]
  6. Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells. Tamura, M., Tanaka, H., Yashiro, A., Osajima, A., Okazaki, M., Kudo, H., Doi, Y., Fujimoto, S., Higashi, K., Nakashima, Y., Hirano, H. J. Am. Soc. Nephrol. (2000) [Pubmed]
  7. Vinculin, VASP, and profilin are coordinately regulated during actin remodeling in epithelial cells, which requires de novo protein synthesis and protein kinase signal transduction pathways. Quinlan, M.P. J. Cell. Physiol. (2004) [Pubmed]
  8. Reversible, activity-dependent targeting of profilin to neuronal nuclei. Birbach, A., Verkuyl, J.M., Matus, A. Exp. Cell Res. (2006) [Pubmed]
  9. Distribution of profilin in fibroblasts correlates with the presence of highly dynamic actin filaments. Buss, F., Temm-Grove, C., Henning, S., Jockusch, B.M. Cell Motil. Cytoskeleton (1992) [Pubmed]
  10. Lipid kinases are novel effectors of the GTPase Rac1. Carpenter, C.L., Tolias, K.F., Van Vugt, A., Hartwig, J. Adv. Enzyme Regul. (1999) [Pubmed]
  11. Increase of hepatic mRNAS of profilin, actin and extracellular matrix proteins after carbon tetrachloride treatment and partial hepatectomy in rats. Nakamura, H., Hirata, K., Yamashiro, K., Hiranuma, K., Shibata, K., Higashi, K., Morita, T., Hirano, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Coordinated expression of five tropomyosin isoforms and beta-actin in astrocytes treated with dibutyryl cAMP and cytochalasin D. Ferrier, R., Had, L., Rabié, A., Faivre-Sarrailh, C. Cell Motil. Cytoskeleton (1994) [Pubmed]
  13. Endothelin-1 mobilizes profilin-1-bound PIP2 in cardiac muscle. Evans, N.J., Walker, J.W. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
  14. Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. Romeo, G.R., Kazlauskas, A. J. Biol. Chem. (2008) [Pubmed]
  15. Rapid increase of profilin-like proteins during liver development. Kishimoto, R., Murano, S., Nagai, K., Nakagawa, H. Biochem. Int. (1984) [Pubmed]
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