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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Schaefer, M. et al.

M. Schaefer, K. Leopold, A. Hinzpeter, A. Heinz, M. Krebs,

Memantine-associated reversal of clozapine-induced weight gain.

INTRODUCTION: Weight gain is a frequently observed adverse event in the treatment with atypical antipsychotics that significantly affects the patients' physical health and treatment compliance. METHODS: We report on a treatment-resistant schizophrenic patient who received an add-on treatment with the low-affinity NMDA antagonist memantine because of cognitive disturbances. RESULTS: During this treatment we observed a marked decrease of clozapine-induced weight gain. The causal relationship to memantine could be demonstrated using an on-off-on design with a significant increase of weight after discontinuation and again a substantial weight loss after re-exposition with memantine. Beside weight, also negative symptoms improved. DISCUSSION: Prospective controlled trials evaluating the safety and possible positive effects of memantine on antipsychotic induced weight gain are needed.[1]

References

Memantine-associated reversal of clozapine-induced weight gain. Schaefer, M., Leopold, K., Hinzpeter, A., Heinz, A., Krebs, M. Pharmacopsychiatry (2007) [Pubmed]

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