Chemical Compound Review:
Memantin 3,5-dimethyladamantan-1-amine
Synonyms:
Memantina, memantine, Memantinum, Ebixa, Exiba, ...
Chladek,
Anzenbacher,
Akhoundova,
Lai,
Weinreb,
Ton,
Ton,
Möbius,
Busch,
Pietra,
Sonders,
Mundlova,
WoldeMussie,
WoldeMussie,
Schadrack,
Ferris,
Stöffler,
Dannhardt,
Villetti,
Arndt,
Reisberg,
Feldmann,
Wheeler,
Waldegger,
Rao,
Kohl,
Zangwill,
Simonato,
Bergamaschi,
Ruiz,
Ruiz,
Karbach,
Periclou,
Chamiot-Clerc,
Maiorino,
Koepsell,
Putzke,
Bassani,
Richard J. Servatius,
Parsons,
Michael J. Tobia,
Bolzoni,
Ventura,
Anzenbacherova,
Abramowitz,
Barbieri,
Fuksa,
Martinkova,
Kevin D. Beck,
Hare,
Hare,
Straube,
Doody,
Gorboulev,
Zieglgänsberger,
Miska,
Spanagel,
Baumann,
Rondelli,
Chun,
Wijono,
Volk,
Micuda,
Lang,
Xilu Jiao,
Wenk,
Diana S. Woodruff-Pak,
Schmitt,
Ulzheimer,
Pestel,
Mahal,
Rammes,
Wheeler,
Spielmanns,
- Pharmacotoxic psychosis after memantine in Parkinson's disease. Riederer, P., Lange, K.W., Kornhuber, J., Danielczyk, W. Lancet (1991)
- Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Nath, A., Haughey, N.J., Jones, M., Anderson, C., Bell, J.E., Geiger, J.D. Ann. Neurol. (2000)
- Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats. Vogels, B.A., Maas, M.A., Daalhuisen, J., Quack, G., Chamuleau, R.A. Hepatology (1997)
- Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: a focus on pentacycloundecane derivatives. Geldenhuys, W.J., Malan, S.F., Bloomquist, J.R., Marchand, A.P., Van der Schyf, C.J. Medicinal research reviews. (2005)
- Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Lagrèze, W.A., Knörle, R., Bach, M., Feuerstein, T.J. Invest. Ophthalmol. Vis. Sci. (1998)
- Memantine reduces hematoma expansion in experimental intracerebral hemorrhage, resulting in functional improvement. Lee, S.T., Chu, K., Jung, K.H., Kim, J., Kim, E.H., Kim, S.J., Sinn, D.I., Ko, S.Y., Kim, M., Roh, J.K. J. Cereb. Blood Flow Metab. (2006)
- Current pharmacotherapy for Alzheimer's disease. Lleó, A., Greenberg, S.M., Growdon, J.H. Annu. Rev. Med. (2006)
- Memantine and catatonic schizophrenia. Thomas, C., Carroll, B.T., Maley, R.T., Jayanti, K., Koduri, A. The American journal of psychiatry. (2005)
- Pharmacokinetic study of memantine in healthy and renally impaired subjects. Periclou, A., Ventura, D., Rao, N., Abramowitz, W. Clin. Pharmacol. Ther. (2006)
- Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization. David, H.N., Ansseau, M., Lemaire, M., Abraini, J.H. Biol. Psychiatry (2006)
- Visual hallucinations from the addition of riluzole to memantine and bupropion. Pittenger, C., Naungayan, C., Kendell, S.F., Coric, V., Malison, R., Krystal, J.H., Sanacora, G.S. Journal of clinical psychopharmacology. (2006)
- Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Chatterton, J.E., Awobuluyi, M., Premkumar, L.S., Takahashi, H., Talantova, M., Shin, Y., Cui, J., Tu, S., Sevarino, K.A., Nakanishi, N., Tong, G., Lipton, S.A., Zhang, D. Nature (2002)
- Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. McRoberts, J.A., Coutinho, S.V., Marvizón, J.C., Grady, E.F., Tognetto, M., Sengupta, J.N., Ennes, H.S., Chaban, V.V., Amadesi, S., Creminon, C., Lanthorn, T., Geppetti, P., Bunnett, N.W., Mayer, E.A. Gastroenterology (2001)
- Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death. Ferrer-Montiel, A.V., Merino, J.M., Blondelle, S.E., Perez-Payà, E., Houghten, R.A., Montal, M. Nat. Biotechnol. (1998)
- Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity. Pellegrini, J.W., Lipton, S.A. Ann. Neurol. (1993)
- Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine. Vorwerk, C.K., Lipton, S.A., Zurakowski, D., Hyman, B.T., Sabel, B.A., Dreyer, E.B. Invest. Ophthalmol. Vis. Sci. (1996)
- Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy. Suzuki, R., Matthews, E.A., Dickenson, A.H. Pain (2001)
- Pharmacology of vertigo/nystagmus/oscillopsia. Straube, A. Curr. Opin. Neurol. (2005)
- Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Van Dam, D., Abramowski, D., Staufenbiel, M., De Deyn, P.P. Psychopharmacology (Berl.) (2005)
- Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Zajaczkowski, W., Frankiewicz, T., Parsons, C.G., Danysz, W. Neuropharmacology (1997)
- Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells. Oliver, D., Ludwig, J., Reisinger, E., Zoellner, W., Ruppersberg, J.P., Fakler, B. Mol. Pharmacol. (2001)
- Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. Chen, H.S., Lipton, S.A. J. Physiol. (Lond.) (1997)
- Induction of apoptosis in cultured human retinal pigment epithelial cells is counteracted by flupirtine. Osborne, N.N., Cazevieille, C., Pergande, G., Wood, J.P. Invest. Ophthalmol. Vis. Sci. (1997)
- Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures. Hare, W.A., WoldeMussie, E., Lai, R.K., Ton, H., Ruiz, G., Chun, T., Wheeler, L. Invest. Ophthalmol. Vis. Sci. (2004)
- Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. Chen, H.S., Pellegrini, J.W., Aggarwal, S.K., Lei, S.Z., Warach, S., Jensen, F.E., Lipton, S.A. J. Neurosci. (1992)
- Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Busch, A.E., Karbach, U., Miska, D., Gorboulev, V., Akhoundova, A., Volk, C., Arndt, P., Ulzheimer, J.C., Sonders, M.S., Baumann, C., Waldegger, S., Lang, F., Koepsell, H. Mol. Pharmacol. (1998)
- Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures. Hare, W.A., WoldeMussie, E., Weinreb, R.N., Ton, H., Ruiz, G., Wijono, M., Feldmann, B., Zangwill, L., Wheeler, L. Invest. Ophthalmol. Vis. Sci. (2004)
- Neuropathologic changes in Alzheimer's disease: potential targets for treatment. Wenk, G.L. The Journal of clinical psychiatry. (2006)
- Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. Villetti, G., Bergamaschi, M., Bassani, F., Bolzoni, P.T., Maiorino, M., Pietra, C., Rondelli, I., Chamiot-Clerc, P., Simonato, M., Barbieri, M. J. Pharmacol. Exp. Ther. (2003)
- Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120. Pittaluga, A., Pattarini, R., Severi, P., Raiteri, M. AIDS (1996)
- Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. Gelbard, H.A., Nottet, H.S., Swindells, S., Jett, M., Dzenko, K.A., Genis, P., White, R., Wang, L., Choi, Y.B., Zhang, D. J. Virol. (1994)
- The NMDA receptor complex: a promising target for novel antiepileptic strategies. Kohl, B.K., Dannhardt, G. Current medicinal chemistry. (2001)
- Comparison of the effects of ketamine and memantine on prolactin and cortisol release in men. a randomized, double-blind, placebo-controlled trial. Hergovich, N., Singer, E., Agneter, E., Eichler, H.G., Graselli, U., Simhandl, C., Jilma, B. Neuropsychopharmacology (2001)
- Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezil. Woodruff-Pak, D.S., Tobia, M.J., Jiao, X., Beck, K.D., Servatius, R.J. Neuropsychopharmacology (2007)
- Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine. Meisner, F., Scheller, C., Kneitz, S., Sopper, S., Neuen-Jacob, E., Riederer, P., ter Meulen, V., Koutsilieri, E. Neuropsychopharmacology (2008)
- The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Rammes, G., Mahal, B., Putzke, J., Parsons, C., Spielmanns, P., Pestel, E., Spanagel, R., Zieglgänsberger, W., Schadrack, J. Neuropharmacology (2001)
- Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Bresink, I., Benke, T.A., Collett, V.J., Seal, A.J., Parsons, C.G., Henley, J.M., Collingridge, G.L. Br. J. Pharmacol. (1996)
- Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. Micuda, S., Mundlova, L., Anzenbacherova, E., Anzenbacher, P., Chladek, J., Fuksa, L., Martinkova, J. Eur. J. Clin. Pharmacol. (2004)
- In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors. De Sarno, P., Bijur, G.N., Zmijewska, A.A., Li, X., Jope, R.S. Neurobiol. Aging (2006)
- Trapping channel block of NMDA-activated responses by amantadine and memantine. Blanpied, T.A., Boeckman, F.A., Aizenman, E., Johnson, J.W. J. Neurophysiol. (1997)
- The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Marvanová, M., Lakso, M., Pirhonen, J., Nawa, H., Wong, G., Castrén, E. Mol. Cell. Neurosci. (2001)
- Memantine: a review of its use in Alzheimer's disease. Robinson, D.M., Keating, G.M. Drugs (2006)
- A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease. Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., Möbius, H.J. Arch. Neurol. (2006)