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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sorting of plasma membrane proteins in epithelial cells.

Proteins follow two routes to reach the correct surface (apical or basolateral) of a polarized epithelial cell: direct sorting from the trans-Golgi network and transcytosis from early endosomes. Several signals have been identified recently that control these sorting events, namely a glycosyl-phosphatidylinositol anchor for apical targeting, a 14-residue cytoplasmic segment of the polymeric immunoglobulin receptor for basolateral targeting, and phosphorylation of a Ser residue for transcytosis of this receptor. The machinery involved is still poorly understood.[1]


  1. Sorting of plasma membrane proteins in epithelial cells. Bomsel, M., Mostov, K. Curr. Opin. Cell Biol. (1991) [Pubmed]
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