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Bomsel, M. et al.

Sorting of plasma membrane proteins in epithelial cells.

Proteins follow two routes to reach the correct surface (apical or basolateral) of a polarized epithelial cell: direct sorting from the trans-Golgi network and transcytosis from early endosomes. Several signals have been identified recently that control these sorting events, namely a glycosyl-phosphatidylinositol anchor for apical targeting, a 14-residue cytoplasmic segment of the polymeric immunoglobulin receptor for basolateral targeting, and phosphorylation of a Ser residue for transcytosis of this receptor. The machinery involved is still poorly understood.[1]

References

Sorting of plasma membrane proteins in epithelial cells. Bomsel, M., Mostov, K. Curr. Opin. Cell Biol. (1991) [Pubmed]

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