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Gene Review

Tgoln1  -  trans-golgi network protein

Mus musculus

Synonyms: AU015504, D6Ertd384e, TGN38, TGN38A, Trans-Golgi network integral membrane protein 1, ...
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Disease relevance of Tgoln1

  • However, some stress conditions, such as infection with vaccinia virus or vesicular stomatitis virus, as well as 20 degrees C or 43 degrees C treatment, resulted in a significant shift of the distribution towards the trans-TGN side of the Golgi stack [1].
  • Collectively, our data suggest that Rab3D modulates a post-TGN trafficking step that is required for osteoclastic bone resorption [2].
  • Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network [3].
  • The mouse hepatitis virus M protein is a triple spanning membrane glycoprotein that, when expressed independently, localizes to trans-Golgi as well as to the trans-Golgi network (TGN) [4].
  • Collectively, these data argue that the TGN becomes enriched in vaccinia virus membrane proteins that facilitate the wrapping event responsible for the formation of the IEV [5].

High impact information on Tgoln1


Biological context of Tgoln1


Anatomical context of Tgoln1


Associations of Tgoln1 with chemical compounds

  • The 11-amino acid cytoplasmic tail of lamp1 contains a tyrosine-based motif that has been previously shown to mediate sorting in the trans-Golgi network and rapid internalization at the plasma membrane [20].
  • Mannose 6-phosphate receptors are cargo molecules that exit the TGN via AP-1-clathrin-coated vesicles [21].
  • We show that directed mutations of residues at a particular corner of the gamma chain prevent recruitment to the TGN in cells and diminish PI-4-P-dependent, but not Arf1-dependent, liposome binding in vitro [22].
  • Treatment with brefeldin A almost completely blocked sulfation, indicating that this modification occurs in the trans-Golgi network [23].
  • High-affinity binding of the AP-1 adaptor complex to trans-golgi network membranes devoid of mannose 6-phosphate receptors [24].

Physical interactions of Tgoln1


Co-localisations of Tgoln1

  • Morphometric analyses indicated that approximately 17% of the MTP signal colocalized with the TGN38, while 33% of the trans-Golgi marker colocalized with the MTP [26].

Regulatory relationships of Tgoln1


Other interactions of Tgoln1


Analytical, diagnostic and therapeutic context of Tgoln1


  1. Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cells. Griffiths, G., Ericsson, M., Krijnse-Locker, J., Nilsson, T., Goud, B., Söling, H.D., Tang, B.L., Wong, S.H., Hong, W. J. Cell Biol. (1994) [Pubmed]
  2. Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Pavlos, N.J., Xu, J., Riedel, D., Yeoh, J.S., Teitelbaum, S.L., Papadimitriou, J.M., Jahn, R., Ross, F.P., Zheng, M.H. Mol. Cell. Biol. (2005) [Pubmed]
  3. Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network. Faucherre, A., Desbois, P., Satre, V., Lunardi, J., Dorseuil, O., Gacon, G. Hum. Mol. Genet. (2003) [Pubmed]
  4. Oligomerization of a trans-Golgi/trans-Golgi network retained protein occurs in the Golgi complex and may be part of its retention. Locker, J.K., Opstelten, D.J., Ericsson, M., Horzinek, M.C., Rottier, P.J. J. Biol. Chem. (1995) [Pubmed]
  5. Assembly of vaccinia virus: the second wrapping cisterna is derived from the trans Golgi network. Schmelz, M., Sodeik, B., Ericsson, M., Wolffe, E.J., Shida, H., Hiller, G., Griffiths, G. J. Virol. (1994) [Pubmed]
  6. A role for phosphatidylinositol transfer protein in secretory vesicle formation. Ohashi, M., Jan de Vries, K., Frank, R., Snoek, G., Bankaitis, V., Wirtz, K., Huttner, W.B. Nature (1995) [Pubmed]
  7. Sorting of plasma membrane proteins in epithelial cells. Bomsel, M., Mostov, K. Curr. Opin. Cell Biol. (1991) [Pubmed]
  8. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Bartke, T., Pohl, C., Pyrowolakis, G., Jentsch, S. Mol. Cell (2004) [Pubmed]
  9. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Urushitani, M., Sik, A., Sakurai, T., Nukina, N., Takahashi, R., Julien, J.P. Nat. Neurosci. (2006) [Pubmed]
  10. Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin. Gil-Torregrosa, B.C., Raúl Castaño, A., Del Val, M. J. Exp. Med. (1998) [Pubmed]
  11. Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. Yeaman, C., Grindstaff, K.K., Wright, J.R., Nelson, W.J. J. Cell Biol. (2001) [Pubmed]
  12. Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation. Payne, A.S., Kelly, E.J., Gitlin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  13. Related signals for endocytosis and basolateral sorting of the asialoglycoprotein receptor. Geffen, I., Fuhrer, C., Leitinger, B., Weiss, M., Huggel, K., Griffiths, G., Spiess, M. J. Biol. Chem. (1993) [Pubmed]
  14. A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes. Mauxion, F., Le Borgne, R., Munier-Lehmann, H., Hoflack, B. J. Biol. Chem. (1996) [Pubmed]
  15. Strain-specific presence of two TGN38 isoforms and absence of TGN41 in mouse. Kasai, K., Takahashi, S., Murakami, K., Nakayama, K. J. Biol. Chem. (1995) [Pubmed]
  16. Expression of regulated secretory proteins is sufficient to generate granule-like structures in constitutively secreting cells. Beuret, N., Stettler, H., Renold, A., Rutishauser, J., Spiess, M. J. Biol. Chem. (2004) [Pubmed]
  17. Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network. Rohrer, J., Kornfeld, R. Mol. Biol. Cell (2001) [Pubmed]
  18. Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. Kantheti, P., Qiao, X., Diaz, M.E., Peden, A.A., Meyer, G.E., Carskadon, S.L., Kapfhamer, D., Sufalko, D., Robinson, M.S., Noebels, J.L., Burmeister, M. Neuron (1998) [Pubmed]
  19. Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. Deneka, M., Neeft, M., Popa, I., van Oort, M., Sprong, H., Oorschot, V., Klumperman, J., Schu, P., van der Sluijs, P. EMBO J. (2003) [Pubmed]
  20. The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane. Rohrer, J., Schweizer, A., Russell, D., Kornfeld, S. J. Cell Biol. (1996) [Pubmed]
  21. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. Meyer, C., Zizioli, D., Lausmann, S., Eskelinen, E.L., Hamann, J., Saftig, P., von Figura, K., Schu, P. EMBO J. (2000) [Pubmed]
  22. Crystal structure of the clathrin adaptor protein 1 core. Heldwein, E.E., Macia, E., Wang, J., Yin, H.L., Kirchhausen, T., Harrison, S.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  23. Biosynthesis of GlyCAM-1, a mucin-like ligand for L-selectin. Crommie, D., Rosen, S.D. J. Biol. Chem. (1995) [Pubmed]
  24. High-affinity binding of the AP-1 adaptor complex to trans-golgi network membranes devoid of mannose 6-phosphate receptors. Zhu, Y., Traub, L.M., Kornfeld, S. Mol. Biol. Cell (1999) [Pubmed]
  25. Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharides. Boulatnikov, I., De Lisle, R.C. J. Biol. Chem. (2004) [Pubmed]
  26. Subcellular localization of microsomal triglyceride transfer protein. Swift, L.L., Zhu, M.Y., Kakkad, B., Jovanovska, A., Neely, M.D., Valyi-Nagy, K., Roberts, R.L., Ong, D.E., Jerome, W.G. J. Lipid Res. (2003) [Pubmed]
  27. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. Greenfield, J.P., Leung, L.W., Cai, D., Kaasik, K., Gross, R.S., Rodriguez-Boulan, E., Greengard, P., Xu, H. J. Biol. Chem. (2002) [Pubmed]
  28. Identification of a mammalian Golgi Sec1p-like protein, mVps45. Tellam, J.T., James, D.E., Stevens, T.H., Piper, R.C. J. Biol. Chem. (1997) [Pubmed]
  29. Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate. Meyer, C., Eskelinen, E.L., Guruprasad, M.R., von Figura, K., Schu, P. J. Cell. Sci. (2001) [Pubmed]
  30. Chromogranin B (secretogranin I) promotes sorting to the regulated secretory pathway of processing intermediates derived from a peptide hormone precursor. Natori, S., Huttner, W.B. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  31. Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking. Varlamov, O., Kalinina, E., Che, F.Y., Fricker, L.D. J. Cell. Sci. (2001) [Pubmed]
  32. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Cai, D., Zhong, M., Wang, R., Netzer, W.J., Shields, D., Zheng, H., Sisodia, S.S., Foster, D.A., Gorelick, F.S., Xu, H., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  33. Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network. Siman, R., Velji, J. J. Neurochem. (2003) [Pubmed]
  34. Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells. Tooze, J., Tooze, S.A. J. Cell Biol. (1986) [Pubmed]
  35. Role of amphiphysin II in somatostatin receptor trafficking in neuroendocrine cells. Sarret, P., Esdaile, M.J., McPherson, P.S., Schonbrunn, A., Kreienkamp, H.J., Beaudet, A. J. Biol. Chem. (2004) [Pubmed]
  36. Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes. Lin, S.X., Mallet, W.G., Huang, A.Y., Maxfield, F.R. Mol. Biol. Cell (2004) [Pubmed]
  37. O-glycosylation of the coronavirus M protein. Differential localization of sialyltransferases in N- and O-linked glycosylation. Locker, J.K., Griffiths, G., Horzinek, M.C., Rottier, P.J. J. Biol. Chem. (1992) [Pubmed]
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