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Zee, R.Y. et al.

Robert Y. L. Zee, Soren Germer, Abraham Thomas, Annaswammy Raji, Brian Rhees, Paul M. Ridker, Klaus Lindpaintner, Gordon H. Williams, David M. Nathan, Mitchell Martin,

C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

OBJECTIVE: C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians. RESEARCH DESIGN AND METHODS: The present investigation was conducted to replicate this previous association, and to further examine the potential association of a set of common CRP gene variants with the prevalence of T2DM in a case-control investigation. A total of 629 T2DM cases (476 Whites, and 153 Blacks), and 579 controls (481 Whites, and 98 Blacks) were examined. Seven CRP variants were evaluated: rs3093059, rs2794521, rs3091244, rs1417938, rs1800947, rs1130864, and rs1205. RESULTS: Using a marker-by-marker logistic regression analysis, adjusting for age, smoking, gender, and body mass index, we found an association of rs3093059 (recessive: OR, 7.01; 95% CI, 1.16-42.22; p=0.03) with T2DM in the white study population, and an association, albeit not statistically significant, of rs2794521 with T2DM in the Black study population. Moreover, further analysis using a haplotype-based analysis showed no evidence for an association of the haplotypes tested with T2DM. CONCLUSION: Further studies are needed to examine the possible involvement of C-reactive protein gene variation in the pathogenesis of type 2 diabetes mellitus.[1]

References

C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study. Zee, R.Y., Germer, S., Thomas, A., Raji, A., Rhees, B., Ridker, P.M., Lindpaintner, K., Williams, G.H., Nathan, D.M., Martin, M. Atherosclerosis (2008) [Pubmed]

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