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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Severe deterioration of psoriasis due to an insulinoma.

We report a case of a 56-year-old woman who presented with a severe exacerbation of psoriasis with concurrent hypoglycaemic episodes. Methotrexate 17.5 mg weekly was required to control her psoriasis. Investigation of her hypoglycaemia showed raised levels of insulin, C-peptide and proinsulin. Radiological investigation showed a tumour at the tail of the pancreas and the diagnosis was insulinoma. A spleen-preserving distal pancreatectomy was performed and the hypoglycaemic symptoms resolved. Immediately following the pancreatectomy, methotrexate was stopped and the patient's psoriasis went into remission. During a 2-year follow-up, she has required only minimal topical treatment for her skin.[1]


  1. Severe deterioration of psoriasis due to an insulinoma. Field, S., Kelly, G., Tobin, A.M., Barragry, J.M., Conlon, K.C., Kirby, B. Clin. Exp. Dermatol. (2008) [Pubmed]
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