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Disease relevance of Insulinoma


High impact information on Insulinoma

  • We evaluated the role of IBi in beta-cells by expression of a MAPK8IP1 antisense RNA in a stable insulinoma beta-cell line [5].
  • High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma [6].
  • Letter: Phenytoin in metastatic insulinoma [7].
  • Here, we show that NCAM-deficient beta cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions and deficient perivascular deposition of ECM components [8].
  • In the current study, we show that IL-1beta induces destruction of INS-1 insulinoma cells, while having no effect on a second insulinoma cell line RIN1046-38 and its engineered derivatives, and that this difference is correlated with a higher level of expression of manganese superoxide dismutase (MnSOD) in the latter cells [9].

Chemical compound and disease context of Insulinoma


Biological context of Insulinoma


Anatomical context of Insulinoma


Gene context of Insulinoma


Analytical, diagnostic and therapeutic context of Insulinoma


  1. "Somatostatinoma": a somatostatin-containing tumor of the endocrine pancreas. Ganda, O.P., Weir, G.C., Soeldner, J.S., Legg, M.A., Chick, W.L., Patel, Y.C., Ebeid, A.M., Gabbay, K.H., Reichlin, S. N. Engl. J. Med. (1977) [Pubmed]
  2. Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. Virgolini, I., Raderer, M., Kurtaran, A., Angelberger, P., Banyai, S., Yang, Q., Li, S., Banyai, M., Pidlich, J., Niederle, B., Scheithauer, W., Valent, P. N. Engl. J. Med. (1994) [Pubmed]
  3. Hypoglycemia unawareness. Gerich, J.E., Mokan, M., Veneman, T., Korytkowski, M., Mitrakou, A. Endocr. Rev. (1991) [Pubmed]
  4. Immunohistochemical study of neuron-specific enolase and CA 19-9 in pancreatic disorders. The value of neuron-specific enolase as a marker for islet cell and nerve tissue. Iwase, K., Kato, K., Nagasaka, A., Miura, K., Kawase, K., Miyakawa, S., Tei, T., Ohtani, S., Inagaki, M., Shinoda, S. Gastroenterology (1986) [Pubmed]
  5. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Waeber, G., Delplanque, J., Bonny, C., Mooser, V., Steinmann, M., Widmann, C., Maillard, A., Miklossy, J., Dina, C., Hani, E.H., Vionnet, N., Nicod, P., Boutin, P., Froguel, P. Nat. Genet. (2000) [Pubmed]
  6. High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma. Okada, Y., Taniguchi, H., Schimada, C. Science (1976) [Pubmed]
  7. Letter: Phenytoin in metastatic insulinoma. Aderka, D., Shaklai, M., Doron, M., Laron, Z., Pinkhas, J., De Vries, A. JAMA (1975) [Pubmed]
  8. Pericytes limit tumor cell metastasis. Xian, X., Håkansson, J., Ståhlberg, A., Lindblom, P., Betsholtz, C., Gerhardt, H., Semb, H. J. Clin. Invest. (2006) [Pubmed]
  9. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. Hohmeier, H.E., Thigpen, A., Tran, V.V., Davis, R., Newgard, C.B. J. Clin. Invest. (1998) [Pubmed]
  10. Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity. Sjöholm, A., Arkhammar, P., Welsh, N., Bokvist, K., Rorsman, P., Hallberg, A., Nilsson, T., Welsh, M., Berggren, P.O. J. Clin. Invest. (1993) [Pubmed]
  11. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. Corbett, J.A., Wang, J.L., Sweetland, M.A., Lancaster, J.R., McDaniel, M.L. J. Clin. Invest. (1992) [Pubmed]
  12. Glucose-induced hypoglycaemia in insulinoma with impaired glucose tolerance. Otani, T. Lancet (2003) [Pubmed]
  13. Calcium antagonist (diltiazem) for reversal of hypoglycaemic symptoms in insulinoma. Taniguchi, H., Murakami, K., Morita, S., Kazumi, T., Yoshino, G., Maeda, M., Baba, S. Lancet (1977) [Pubmed]
  14. Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. Dunne, M.J., Bullett, M.J., Li, G.D., Wollheim, C.B., Petersen, O.H. EMBO J. (1989) [Pubmed]
  15. Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas. Alabraba, E.B., Taniere, P., Reynolds, G.M., Stewart, P.M., Wigmore, S.J., Bramhall, S.R. Endocr. Relat. Cancer (2007) [Pubmed]
  16. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Westermark, P., Wernstedt, C., Wilander, E., Hayden, D.W., O'Brien, T.D., Johnson, K.H. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  17. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues. Ohagi, S., LaMendola, J., LeBeau, M.M., Espinosa, R., Takeda, J., Smeekens, S.P., Chan, S.J., Steiner, D.F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  18. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Bartfai, T., Langel, U., Bedecs, K., Andell, S., Land, T., Gregersen, S., Ahrén, B., Girotti, P., Consolo, S., Corwin, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expression. Robinson, G.L., Cordle, S.R., Henderson, E., Weil, P.A., Teitelman, G., Stein, R. Mol. Cell. Biol. (1994) [Pubmed]
  20. Ca2+-dependent protein phosphorylation and insulin release in intact hamster insulinoma cells. Inhibition by trifluoperazine. Schubart, U.K., Fleischer, N., Erlichman, J. J. Biol. Chem. (1980) [Pubmed]
  21. GLUT2 surface expression and intracellular transport via the constitutive pathway in pancreatic beta cells and insulinoma: evidence for a block in trans-Golgi network exit by brefeldin A. Thorens, B., Gérard, N., Dériaz, N. J. Cell Biol. (1993) [Pubmed]
  22. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. Brown, H., Larsson, O., Bränström, R., Yang, S.N., Leibiger, B., Leibiger, I., Fried, G., Moede, T., Deeney, J.T., Brown, G.R., Jacobsson, G., Rhodes, C.J., Braun, J.E., Scheller, R.H., Corkey, B.E., Berggren, P.O., Meister, B. EMBO J. (1998) [Pubmed]
  23. Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells. Blondel, O., Moody, M.M., Depaoli, A.M., Sharp, A.H., Ross, C.A., Swift, H., Bell, G.I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  24. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. Kulkarni, R.N., Wang, Z.L., Wang, R.M., Hurley, J.D., Smith, D.M., Ghatei, M.A., Withers, D.J., Gardiner, J.V., Bailey, C.J., Bloom, S.R. J. Clin. Invest. (1997) [Pubmed]
  25. NIH conference. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Gorden, P., Comi, R.J., Maton, P.N., Go, V.L. Ann. Intern. Med. (1989) [Pubmed]
  26. Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Nishi, M., Chan, S.J., Nagamatsu, S., Bell, G.I., Steiner, D.F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  27. Serpin peptidase inhibitor clade A member 1 as a potential marker for malignancy in insulinomas. de Sá, S.V., Corrêa-Giannella, M.L., Machado, M.C., Krogh, K., de Almeida, M.Q., Albergaria Pereira, M.A., Coelho Siqueira, S.A., Patzina, R.A., Ibuki, F.S., Sogayar, M.C., Machado, M.C., Giannella-Neto, D. Clin. Cancer Res. (2007) [Pubmed]
  28. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. Goto, Y., De Silva, M.G., Toscani, A., Prabhakar, B.S., Notkins, A.L., Lan, M.S. J. Biol. Chem. (1992) [Pubmed]
  29. Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Wang, X., Li, H., De Leo, D., Guo, W., Koshkin, V., Fantus, I.G., Giacca, A., Chan, C.B., Der, S., Wheeler, M.B. Diabetes (2004) [Pubmed]
  30. An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures. Bennett, R.G., Hamel, F.G., Duckworth, W.C. Diabetes (2003) [Pubmed]
  31. Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. Rochlitz, H., Voigt, A., Lankat-Buttgereit, B., Göke, B., Heimberg, H., Nauck, M.A., Schiemann, U., Schatz, H., Pfeiffer, A.F. Diabetologia (2000) [Pubmed]
  32. Influence of a transplantable insulinoma on the pancreatic status of insulin and pancreatic polypeptide in the rat. O'Hare, M.M., Shaw, C., Swanston-Flatt, S.K., Marcelli, M., Buchanan, K.D., Flatt, P.R. Diabetologia (1985) [Pubmed]
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