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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

beta-Catenin is a Nek2 substrate involved in centrosome separation.

beta-Catenin plays important roles in cell adhesion and gene transcription, and has been shown recently to be essential for the establishment of a bipolar mitotic spindle. Here we show that beta-catenin is a component of interphase centrosomes and that stabilization of beta-catenin, mimicking mutations found in cancers, induces centrosome splitting. Centrosomes are held together by a dynamic linker regulated by Nek2 kinase and its substrates C-Nap1 (centrosomal Nek2-associated protein 1) and Rootletin. We show that beta-catenin binds to and is phosphorylated by Nek2, and is in a complex with Rootletin. In interphase, beta-catenin colocalizes with Rootletin between C-Nap1 puncta at the proximal end of centrioles, and this localization is dependent on C-Nap1 and Rootletin. In mitosis, when Nek2 activity increases, beta-catenin localizes to centrosomes at spindle poles independent of Rootletin. Increased Nek2 activity disrupts the interaction of Rootletin with centrosomes and results in binding of beta-catenin to Rootletin-independent sites on centrosomes, an event that is required for centrosome separation. These results identify beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation.[1]


  1. beta-Catenin is a Nek2 substrate involved in centrosome separation. Bahmanyar, S., Kaplan, D.D., Deluca, J.G., Giddings, T.H., O'Toole, E.T., Winey, M., Salmon, E.D., Casey, P.J., Nelson, W.J., Barth, A.I. Genes Dev. (2008) [Pubmed]
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