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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment.

Seven of nine depressed patients experienced a 4.3-fold increase in rated euphoria and activation following 30 mg d-amphetamine in a replicated dose, double blind study. d-Amphetamine was 2 to 2.3-fold more effective in producing activation, euphoria, and antidepressant effects than the same dose of l-amphetamine. Co-treatment with lithium carbonate produced a 60% (P less than 0.001) attenuation of the activation and euphoria responses to d-amphetamine. The responses to l-amphetamine were almost completely abolished by lithium. This study raises the possibility of lithium carbonate use as an adjunct in the treatment of amphetamine addiction.[1]

References

  1. Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. Van Kammen, D.P., Murphy, D.L. Psychopharmacologia. (1975) [Pubmed]
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