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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function.The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC).A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted.Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing.Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherindownregulation in thyroid papillary neoplasia.[1]
