Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Franco, C. et al.

Celina Franco, Josef Koranyi, John Brandberg, Lars Lönn, Bengt-Ke Bengtsson, Johan Svensson, Gudmundur Johannsson,

The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women.

CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action.[1]

References

The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. Franco, C., Koranyi, J., Brandberg, J., Lönn, L., Bengtsson, B.K., Svensson, J., Johannsson, G. Growth Horm. IGF Res. (2009) [Pubmed]

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