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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders.

The thalamus has a strong nonphotic influence on sleep, circadian rhythmicity, pineal melatonin production, and secretion. The opening of the sleep gate for nonrapid eye movement sleep is a thalamic function but it is assisted by melatonin which acts by promoting spindle formation. Thus, melatonin has a modulatory influence on sleep onset and maintenance. A remarkable similarity exists between spindle behavior, circadian rhythmicity, and pineal melatonin production throughout life. Together, the thalamic and chronobiological control of sleep leads to a new and improved understanding of the pathophysiology of circadian rhythm sleep disorders and also of the principles of sleep hygiene interventions.[1]

References

  1. The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders. Jan, J.E., Reiter, R.J., Wasdell, M.B., Bax, M. J. Pineal Res. (2009) [Pubmed]
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