Disease relevance of Sleep Disorders, Circadian Rhythm

• Hypersensitivity of melatonin suppression in response to light in patients with delayed sleep phase syndrome [1].
• It has been suggested melatonin may play an important therapeutic role in the treatment of migraines and other types of headaches, particularly those related to delayed sleep phase syndrome [2].

High impact information on Sleep Disorders, Circadian Rhythm

• Familial advanced sleep phase syndrome (FASPS) is an autosomal dominant circadian rhythm variant; affected individuals are "morning larks" with a 4-hour advance of the sleep, temperature, and melatonin rhythms [3].
• Effects of light and chronotherapy on human circadian rhythms in delayed sleep phase syndrome: cytokines, cortisol, growth hormone, and the sleep-wake cycle [4].
• A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference [5].
• Disorders in the timing and duration of night sleep in AE subjects manifested as either a permanent advance (advanced sleep phase syndrome, ASPS) or delay (delayed sleep phase syndrome, DSPS) [6].
• Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12) [7].

Chemical compound and disease context of Sleep Disorders, Circadian Rhythm

• Modafinil : a review of its use in excessive sleepiness associated with obstructive sleep apnoea/hypopnoea syndrome and shift work sleep disorder [8].
• Management of shift work sleep disorder: Alice in Wonderland redux [9]?
• Based on such estimations of circadian phase, we will recommend appropriate timing of bright light and/or melatonin in the different circadian rhythm sleep disorders [10].

Gene context of Sleep Disorders, Circadian Rhythm

• We studied the association between the AA-NAT gene and delayed sleep phase syndrome (DSPS) [11].
• Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome [12].
• Recent studies have shown that mutations in hPER2 are associated with autosomal-dominant familial advanced-sleep-phase syndrome [13].
• These results do not support Clock 3111C as a marker for diurnal preference, tau, or delayed sleep phase syndrome in humans [14].
• Article reviewed: Familial advanced sleep phase syndrome [15].

Analytical, diagnostic and therapeutic context of Sleep Disorders, Circadian Rhythm

• Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders [16].
• The occurrence of headache and its change after treatment with melatonin 5 mg were studied in 30 patients with delayed sleep phase syndrome [17].
• The fact that biological rhythm disorders like delayed sleep phase syndrome (DSPS), Jet lag, shift-work disorders, seasonal effective disorder (SAD) respond well either to phototherapy or melatonin adds further support to the concept that melatonin is involved in the pathogenesis of these conditions [18].
• Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study [19].

References