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Johnson, J.R. et al.

James R. Johnson, Michael A. Kuskowski, Krista Owens, Connie Clabots, Randall S. Singer,

Virulence genotypes and phylogenetic background of fluoroquinolone-resistant and susceptible Escherichia coli urine isolates from dogs with urinary tract infection.

The origins and virulence potential of fluoroquinolone-resistant (FQ-R) Escherichia coli from dogs with urinary tract infection (UTI) are undefined. Therefore, fluoroquinolone-resistant (n=38) or susceptible (n=62) E. coli urine isolates from dogs with UTI were characterized for phylogenetic group (A, B1, B2, D) and 61 virulence-associated genes by multiplex PCR, then were compared according to these characteristics. Compared with fluoroquinolone-susceptible (FQ-S) isolates, the fluoroquinolone-resistant isolates exhibited significantly lower prevalences for most virulence genes studied (albeit higher prevalences for several, including iutA: aerobactin receptor), significantly fewer virulence genes per isolate, and shifts away from virulence-associated group B2. Nonetheless, 26% of fluoroquinolone-resistant isolates qualified as extraintestinal pathogenic E. coli (ExPEC), suggesting possible human virulence potential. The findings call into question whether the fluoroquinolone-resistant E. coli encountered in dogs arise through conversion of fluoroquinolone-susceptible canine resident strains to resistance, or instead are imported from an external source. They also identify dogs as a possible reservoir of drug-resistant ExPEC for transmission to other pets and humans.[1]

References

Virulence genotypes and phylogenetic background of fluoroquinolone-resistant and susceptible Escherichia coli urine isolates from dogs with urinary tract infection. Johnson, J.R., Kuskowski, M.A., Owens, K., Clabots, C., Singer, R.S. Vet. Microbiol. (2009) [Pubmed]

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