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Chemical Compound Review

aerobactin     3-[[(1S)-1-carboxy-5- (ethanoyl-hydroxy...

Synonyms: AG-E-81910, CHEBI:18157, HMDB04051, KST-1A3335, CTK1A4339, ...
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Disease relevance of C05554


High impact information on C05554


Chemical compound and disease context of C05554


Biological context of C05554


Anatomical context of C05554

  • The Iut- mutant was found in smaller numbers in the duodenum, suggesting that aerobactin conferred a significant selective advantage for colonization of this intestinal segment [18].
  • In rats with negative urine culture after augmentation experimental cystitis was induced by the transurethral inoculation of E. coli C5, with type I pili and aerobactin or E. coli C92 with type I pili, P fimbriae and aerobactin at a concentration of 10(5) colony forming units per 0.3 ml [19].
  • One of these proteins, IucD439, was purified to homogeneity from the soluble fraction of the cell lysates, and it was capable of participating in the biosynthesis of aerobactin, as determined in vitro by a cell-free system and in vivo by a cross-feeding bioassay [20].
  • The characteristics exhibited by virulent strains were invasion for HeLa and chicken fibroblast cells, serum resistance, colicin V, and aerobactin production [21].
  • All samples except the last cervix swab contained isolates of serotype O12:K1:H7, which produced adhesins, P fimbriae, type I fimbriae and the iron-chelator aerobactin [22].

Associations of C05554 with other chemical compounds

  • In support of this notion we demonstrate specific binding of the Fe3+ hydroxamate compounds ferrichrome, aerobactin, and coprogen, which are transported via the Fhu system, to the periplasmic FhuD protein, and no binding of the transport inactive ferrichrome A, ferric citrate, and iron sulfate [23].
  • The results of bioassays and DNA-DNA hybridization experiments indicated that pathogenic strains of S. typhi produced enterochelin but not aerobactin [24].
  • The effect of serum and serum proteins on enterobactin- and aerobactin-mediated utilization of transferrin iron has been investigated [25].
  • Certain of the newly detected VF genes, e.g., fyuA (yersiniabactin; 76%) and focG (F1C fimbriae; 25%), were as prevalent or more prevalent than their more familiar traditional counterparts, e.g., iut (aerobactin; 57%) and sfaS (S fimbriae; 14%), thus possibly offering additional useful targets for preventive interventions [26].
  • Virulence factors associated with APEC include type 1 and P fimbriae, curli, aerobactin, lipopolysaccharide (LPS), K1 capsular antigen, temperature-sensitive hemagglutinin (Tsh), and an uncharacterized pathogen-specific chromosomal region (the 0-min region) [27].

Gene context of C05554


Analytical, diagnostic and therapeutic context of C05554


  1. Aerobactin-mediated iron uptake: a virulence determinant in enteropathogenic Escherichia coli? Williams, P.H., Roberts, M. Lancet (1985) [Pubmed]
  2. The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island. Vokes, S.A., Reeves, S.A., Torres, A.G., Payne, S.M. Mol. Microbiol. (1999) [Pubmed]
  3. Activity and specificity of a mouse monoclonal antibody to ferric aerobactin. le Roy, D., Expert, D., Razafindratsita, A., Deroussent, A., Cosme, J., Bohuon, C., Andremont, A. Infect. Immun. (1992) [Pubmed]
  4. Serotypes, hemagglutinins, siderophore synthesis, and serum resistance of Klebsiella isolates causing human urinary tract infections. Podschun, R., Sievers, D., Fischer, A., Ullmann, U. J. Infect. Dis. (1993) [Pubmed]
  5. Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron. D'Autreaux, B., Touati, D., Bersch, B., Latour, J.M., Michaud-Soret, I. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Observation of binding and polymerization of Fur repressor onto operator-containing DNA with electron and atomic force microscopes. Le Cam, E., Frechon, D., Barray, M., Fourcade, A., Delain, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Virulence factors in Escherichia coli urinary tract infection. Johnson, J.R. Clin. Microbiol. Rev. (1991) [Pubmed]
  8. Evidence of an unusually long operator for the fur repressor in the aerobactin promoter of Escherichia coli. Escolar, L., Pérez-Martín, J., de Lorenzo, V. J. Biol. Chem. (2000) [Pubmed]
  9. Relative availability of transferrin-bound iron and cell-derived iron to aerobactin-producing and enterochelin-producing strains of Escherichia coli and to other microorganisms. Brock, J.H., Williams, P.H., Licéaga, J., Wooldridge, K.G. Infect. Immun. (1991) [Pubmed]
  10. Cloning and nucleotide sequence of the pvdA gene encoding the pyoverdin biosynthetic enzyme L-ornithine N5-oxygenase in Pseudomonas aeruginosa. Visca, P., Ciervo, A., Orsi, N. J. Bacteriol. (1994) [Pubmed]
  11. Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli. de Lorenzo, V., Neilands, J.B. J. Bacteriol. (1986) [Pubmed]
  12. Cloning and expression of the fhu genes involved in iron(III)-hydroxamate uptake by Escherichia coli. Fecker, L., Braun, V. J. Bacteriol. (1983) [Pubmed]
  13. The significance of the difference in bacterial adherence between bladder and ileum using rat ileal augmented bladder. Nakano, Y., Fujisawa, M., Matsui, T., Arakawa, S., Kamidono, S. J. Urol. (1999) [Pubmed]
  14. Metalloregulation in vitro of the aerobactin promoter of Escherichia coli by the Fur (ferric uptake regulation) protein. Escolar, L., de Lorenzo, V., Pérez-Martín, J. Mol. Microbiol. (1997) [Pubmed]
  15. Metal ion regulation of gene expression. Fur repressor-operator interaction at the promoter region of the aerobactin system of pColV-K30. de Lorenzo, V., Giovannini, F., Herrero, M., Neilands, J.B. J. Mol. Biol. (1988) [Pubmed]
  16. The organization of intercistronic regions of the aerobactin operon of pColV-K30 may account for the differential expression of the iucABCD iutA genes. Martínez, J.L., Herrero, M., de Lorenzo, V. J. Mol. Biol. (1994) [Pubmed]
  17. Characterization of plasmids encoding the adherence factor of enteropathogenic Escherichia coli. Nataro, J.P., Maher, K.O., Mackie, P., Kaper, J.B. Infect. Immun. (1987) [Pubmed]
  18. Role of aerobactin in systemic spread of an opportunistic strain of Escherichia coli from the intestinal tract of gnotobiotic lambs. Der Vartanian, M., Jaffeux, B., Contrepois, M., Chavarot, M., Girardeau, J.P., Bertin, Y., Martin, C. Infect. Immun. (1992) [Pubmed]
  19. Bacterial adherence in a rat bladder augmentation model: ileocystoplasty versus colocystoplasty. Sakai, Y., Fujisawa, M., Nakano, Y., Miyazaki, S., Arakawa, S., Kamidono, S. J. Urol. (2000) [Pubmed]
  20. Construction and biochemical characterization of recombinant cytoplasmic forms of the IucD protein (lysine:N6-hydroxylase) encoded by the pColV-K30 aerobactin gene cluster. Thariath, A., Socha, D., Valvano, M.A., Viswanatha, T. J. Bacteriol. (1993) [Pubmed]
  21. Virulence factors of avian Escherichia coli. Vidotto, M.C., Müller, E.E., de Freitas, J.C., Alfieri, A.A., Guimarães, I.G., Santos, D.S. Avian Dis. (1990) [Pubmed]
  22. Characterization of Escherichia coli serotype O12:K1:H7 isolates from an immunocompetent carrier with a history of spontaneous abortion and septicemia. Blum-Oehler, G., Heesemann, J., Kranzfelder, D., Scheutz, F., Hacker, J. Eur. J. Clin. Microbiol. Infect. Dis. (1997) [Pubmed]
  23. Iron (III) hydroxamate transport into Escherichia coli. Substrate binding to the periplasmic FhuD protein. Köster, W., Braun, V. J. Biol. Chem. (1990) [Pubmed]
  24. Immune response to the iron-deprivation-induced proteins of Salmonella typhi in typhoid fever. Fernandez-Beros, M.E., Gonzalez, C., McIntosh, M.A., Cabello, F.C. Infect. Immun. (1989) [Pubmed]
  25. Effect of serum albumin on siderophore-mediated utilization of transferrin iron. Konopka, K., Neilands, J.B. Biochemistry (1984) [Pubmed]
  26. Ongoing horizontal and vertical transmission of virulence genes and papA alleles among Escherichia coli blood isolates from patients with diverse-source bacteremia. Johnson, J.R., O'Bryan, T.T., Kuskowski, M., Maslow, J.N. Infect. Immun. (2001) [Pubmed]
  27. Role of avian pathogenic Escherichia coli virulence factors in bacterial interaction with chicken heterophils and macrophages. Mellata, M., Dho-Moulin, M., Dozois, C.M., Curtiss, R., Lehoux, B., Fairbrother, J.M. Infect. Immun. (2003) [Pubmed]
  28. Iron specificity of the Fur-dependent regulation of the biosynthesis of the manganese-containing superoxide dismutase in Escherichia coli. Privalle, C.T., Fridovich, I. J. Biol. Chem. (1993) [Pubmed]
  29. Iron, siderophores, and the pursuit of virulence: independence of the aerobactin and enterochelin iron uptake systems in Escherichia coli. Williams, P.H., Carbonetti, N.H. Infect. Immun. (1986) [Pubmed]
  30. Virulence of iron transport mutants of Shigella flexneri and utilization of host iron compounds. Lawlor, K.M., Daskaleros, P.A., Robinson, R.E., Payne, S.M. Infect. Immun. (1987) [Pubmed]
  31. Virulence properties of Escherichia coli isolated from ostriches with respiratory disease. Knöbl, T., Baccaro, M.R., Moreno, A.M., Gomes, T.A., Vieira, M.A., Ferreira, C.S., Ferreira, A.J. Vet. Microbiol. (2001) [Pubmed]
  32. Sequence analysis demonstrates the conservation of fimH and variability of fimA throughout avian pathogenic Escherichia coli (APEC). Vandemaele, F., Vandekerchove, D., Vereecken, M., Derijcke, J., Dho-Moulin, M., Goddeeris, B.M. Vet. Res. (2003) [Pubmed]
  33. Aerobactin iron transport genes commonly encoded by certain ColV plasmids occur in the chromosome of a human invasive strain of Escherichia coli K1. Valvano, M.A., Crosa, J.H. Infect. Immun. (1984) [Pubmed]
  34. Isolation and properties of N epsilon-hydroxylysine:acetyl coenzyme A N epsilon-transacetylase from Escherichia coli pABN11. Coy, M., Paw, B.H., Bindereif, A., Neilands, J.B. Biochemistry (1986) [Pubmed]
  35. Production of the siderophore aerobactin by a halophilic pseudomonad. Buyer, J.S., de Lorenzo, V., Neilands, J.B. Appl. Environ. Microbiol. (1991) [Pubmed]
  36. New aerobactin-mediated iron uptake system in a septicemia-causing strain of Enterobacter cloacae. Crosa, L.M., Wolf, M.K., Actis, L.A., Sanders-Loehr, J., Crosa, J.H. J. Bacteriol. (1988) [Pubmed]
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