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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Prevalence


Psychiatry related information on Prevalence


High impact information on Prevalence

  • The overall prevalences were 12.6 percent for resistance to any of the four drugs [corrected] (range, 2.3 to 42.4 percent) and 2.2 percent for multidrug resistance (range, 0 to 22.1 percent) [11].
  • For women who used multivitamins without folic acid during the first 6 weeks of pregnancy and women who used multivitamins containing folic acid beginning after 7 or more weeks of pregnancy, the prevalences were similar to that of the nonusers and the prevalence ratios were close to 1.0 [12].
  • The simple restriction fragment length polymorphism pattern of the IVS 1 probe was exploited by comparing 113 IDDM patients with 177 healthy controls to show increased prevalences in IDDM of the 12-kb (P less than 0.0001) and 4-kb (P less than 0.0001) fragments [13].
  • Prevalences in the prolonged, intermediate, and little or no groups at age 17 were 42 (95% CI 31-52)%, 36 (28-44)%, and 65 (56-74)% (p = 0.02, trend test) for atopy, respectively, and 8 (6-10)%, 23 (21-25)%, and 54 (52-56)% (p = 0.0001, trend test) for substantial atopy [14].
  • Prevalences were 1% and 72%, respectively, in patients with fewer than 200 CD4 cells/mm3, and 8.4% and 25.5%, respectively, in those with 600 CD4 cells/mm3 (P < 0.001 for both comparisons) [15].

Chemical compound and disease context of Prevalence


Biological context of Prevalence

  • No significant differences were found in the prevalences of C3 phenotypes or the S and F gene frequencies among the groups studied [21].
  • The prevalences of heterozygotes for F V G1691A and F II G20210A were not significantly different between cases and controls (6.3% v 6.4% and 5.9% v 3.4% among cases and controls, respectively) [22].
  • High prevalences and elevated Ab levels to LSA-1, directed primarily, although not exclusively, to the repetitive region, were detected in sera of individuals from one moderately high and two low transmission malaria-endemic areas (prevalences of 97%, 75, and 77%, respectively) [23].
  • RESULTS: The frequency of the C/C(-13910) genotype defining lactase non-persistence was well in agreement in this study with published figures for the prevalences of adult-type hypolactasia in Africans and Whites [24].
  • RESULTS: Adolescents with the HW phenotype had significantly higher prevalences of all metabolic risk factors except elevated fasting glucose than did those without the HW phenotype [25].

Anatomical context of Prevalence


Associations of Prevalence with chemical compounds

  • Chile has one of the highest prevalences of cholesterol gallstone disease in the world [31].
  • Prevalences of glucose tolerance categories (1999 WHO criteria) were adjusted for sample probabilities [32].
  • RESULTS: Serum homocysteine levels, serum folate levels, and the prevalences of folate deficiency and anemia were not associated with depression status [33].
  • The point prevalences of CFS were thus 0.3% (95% confidence interval [CI], 0% to 0.6%), 0.4% (95% CI, 0% to 0.8%), and 1.0% (95% CI, 0.4% to 1.6%) using the Centers for Disease Control and Prevention, British, and Australian case definitions, respectively [34].
  • Although the prevalences of high fasting serum retinyl esters concentration and low BMD were both substantial in this sample, there were no significant associations between fasting serum retinyl esters and any measure of bone mineral status [35].

Gene context of Prevalence

  • Among these families (24 with facioscapulohumeral disease, 10 with Friedreich's ataxia, and 15 with schizophrenia) the prevalences of TPO Ab and Tg Ab were 27.8% and 26.7%, respectively, in women and 9.2% and 11.7%, respectively, in men [36].
  • The importance of both the CYP1A1 exon 7 (ile:val) and GSTM1 (0/0) polymorphisms in oral cancer susceptibility was assessed by examining polymorphic prevalences in 135 patients with oral cancer and 135 noncancer controls frequency-matched by age at diagnosis (+/- 5 years), race, sex, and institute of patient recruitment [37].
  • Statistical comparisons between the TGPO aAb prevalences in the various groups showed that TGPO aAb could be used as a parameter to distinguish between the groups of Hashimoto's and Graves' patients and between the women with post-partum thyroiditis and the post-partum women with only Tg and/or TPO aAb established during early pregnancy [38].
  • OBJECTIVE: In thyroid tumours, ras, Gs alpha, p53 mutations and ret/PTC rearrangement have been reported with variable prevalences in different geographical regions [28].
  • CONCLUSION: There was no significant difference in the prevalences of HLA-DPB1 alleles between Taiwanese patients with RA and healthy controls [39].

Analytical, diagnostic and therapeutic context of Prevalence


  1. Screening men for prostate and colorectal cancer in the United States: does practice reflect the evidence? Sirovich, B.E., Schwartz, L.M., Woloshin, S. JAMA (2003) [Pubmed]
  2. Serum levels of prostate-specific antigen among Japanese-American and native Japanese men. Shibata, A., Whittemore, A.S., Imai, K., Kolonel, L.N., Wu, A.H., John, E.M., Stamey, T.A., Paffenbarger, R.S. J. Natl. Cancer Inst. (1997) [Pubmed]
  3. ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases. Rieger, M., Mannucci, P.M., Kremer Hovinga, J.A., Herzog, A., Gerstenbauer, G., Konetschny, C., Zimmermann, K., Scharrer, I., Peyvandi, F., Galbusera, M., Remuzzi, G., Böhm, M., Plaimauer, B., Lämmle, B., Scheiflinger, F. Blood (2005) [Pubmed]
  4. Accumulation of genetic abnormalities during neoplastic progression in Barrett's esophagus. Krishnadath, K.K., Tilanus, H.W., van Blankenstein, M., Hop, W.C., Teijgeman, R., Mulder, A.H., Bosman, F.T., van Dekken, H. Cancer Res. (1995) [Pubmed]
  5. Prevalence and correlates of aortic regurgitation in American Indians: the Strong Heart Study. Lebowitz, N.E., Bella, J.N., Roman, M.J., Liu, J.E., Fishman, D.P., Paranicas, M., Lee, E.T., Fabsitz, R.R., Welty, T.K., Howard, B.V., Devereux, R.B. J. Am. Coll. Cardiol. (2000) [Pubmed]
  6. Natural recovery and treatment-seeking in pathological gambling: results of two U.S. national surveys. Slutske, W.S. The American journal of psychiatry. (2006) [Pubmed]
  7. Epidemiology and diagnosis of depression in late life. Mulsant, B.H., Ganguli, M. The Journal of clinical psychiatry. (1999) [Pubmed]
  8. Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu. Zhang, Z.X., Zahner, G.E., Román, G.C., Liu, J., Hong, Z., Qu, Q.M., Liu, X.H., Zhang, X.J., Zhou, B., Wu, C.B., Tang, M.N., Hong, X., Li, H. Arch. Neurol. (2005) [Pubmed]
  9. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002. Ioannou, G.N., Boyko, E.J., Lee, S.P. Am. J. Gastroenterol. (2006) [Pubmed]
  10. Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy. Buvat, J., Lemaire, A. J. Urol. (1997) [Pubmed]
  11. Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. Pablos-Méndez, A., Raviglione, M.C., Laszlo, A., Binkin, N., Rieder, H.L., Bustreo, F., Cohn, D.L., Lambregts-van Weezenbeek, C.S., Kim, S.J., Chaulet, P., Nunn, P. N. Engl. J. Med. (1998) [Pubmed]
  12. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. Milunsky, A., Jick, H., Jick, S.S., Bruell, C.L., MacLaughlin, D.S., Rothman, K.J., Willett, W. JAMA (1989) [Pubmed]
  13. Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-DQ. Michelsen, B., Lernmark, A. J. Clin. Invest. (1987) [Pubmed]
  14. Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old. Saarinen, U.M., Kajosaari, M. Lancet (1995) [Pubmed]
  15. Tuberculin and anergy testing in HIV-seropositive and HIV-seronegative persons. Pulmonary Complications of HIV Infection Study Group. Markowitz, N., Hansen, N.I., Wilcosky, T.C., Hopewell, P.C., Glassroth, J., Kvale, P.A., Mangura, B.T., Osmond, D., Wallace, J.M., Rosen, M.J., Reichman, L.B. Ann. Intern. Med. (1993) [Pubmed]
  16. Clustering of cardiovascular risk factors in urban Asian Indians. Ramachandran, A., Snehalatha, C., Latha, E., Satyavani, K., Vijay, V. Diabetes Care (1998) [Pubmed]
  17. Effects of a traditional lifestyle on obesity in Pima Indians. Ravussin, E., Valencia, M.E., Esparza, J., Bennett, P.H., Schulz, L.O. Diabetes Care (1994) [Pubmed]
  18. Fenoprofen, aspirin, and gold induction in rheumatoid arthritis. Davis, J.D., Turner, R.A., Collins, R.L., Ruchte, I.R., Kaufmann, J.S. Clin. Pharmacol. Ther. (1977) [Pubmed]
  19. Lipid abnormalities associated with urinary albumin excretion rate in Taiwanese type 2 diabetic patients. Tseng, C.H. Kidney Int. (2005) [Pubmed]
  20. Discriminative criteria for Neisseria meningitidis isolates that are moderately susceptible to penicillin and ampicillin. Campos, J., Trujillo, G., Seuba, T., Rodriguez, A. Antimicrob. Agents Chemother. (1992) [Pubmed]
  21. Third component of complement in cystic fibrosis. Holzhauer, R.J., Van Ess, J.D., Schwartz, R.H. Am. J. Hum. Genet. (1976) [Pubmed]
  22. Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. Inbal, A., Freimark, D., Modan, B., Chetrit, A., Matetzky, S., Rosenberg, N., Dardik, R., Baron, Z., Seligsohn, U. Blood (1999) [Pubmed]
  23. Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. Fidock, D.A., Gras-Masse, H., Lepers, J.P., Brahimi, K., Benmohamed, L., Mellouk, S., Guerin-Marchand, C., Londono, A., Raharimalala, L., Meis, J.F. J. Immunol. (1994) [Pubmed]
  24. A genetic test which can be used to diagnose adult-type hypolactasia in children. Rasinperä, H., Savilahti, E., Enattah, N.S., Kuokkanen, M., Tötterman, N., Lindahl, H., Järvelä, I., Kolho, K.L. Gut (2004) [Pubmed]
  25. Clustering of metabolic abnormalities in adolescents with the hypertriglyceridemic waist phenotype. Esmaillzadeh, A., Mirmiran, P., Azizi, F. Am. J. Clin. Nutr. (2006) [Pubmed]
  26. Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. O'Brien, K.D., McDonald, T.O., Chait, A., Allen, M.D., Alpers, C.E. Circulation (1996) [Pubmed]
  27. Multiple endocrine neoplasia type 1: a 10-year prospective screening study in four kindreds. Skogseid, B., Eriksson, B., Lundqvist, G., Lörelius, L.E., Rastad, J., Wide, L., Akerström, G., Oberg, K. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  28. Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population. Park, K.Y., Koh, J.M., Kim, Y.I., Park, H.J., Gong, G., Hong, S.J., Ahn, I.M. Clin. Endocrinol. (Oxf) (1998) [Pubmed]
  29. Revisiting autoantibody profiles in systemic lupus erythematosus. Olhoffer, I.H., Peng, S.L., Craft, J. J. Rheumatol. (1997) [Pubmed]
  30. The diagnosis of urinary tract infections among pregnant women in rural Tanzania; prevalences and correspondence between different diagnostic methods. Olsen, B.E., Hinderaker, S.G., Lie, R.T., Gasheka, P., Baerheim, A., Bergsjø, P., Kvåle, G. Acta obstetricia et gynecologica Scandinavica. (2000) [Pubmed]
  31. Increased activity in the biliary Con A-binding fraction accounts for the difference in crystallization behavior in bile from Chilean gallstone patients compared with Dutch gallstone patients. Miquel, J.F., Van Der Putten, J., Pimentel, F., Mok, K.S., Groen, A.K. Hepatology (2001) [Pubmed]
  32. High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Rathmann, W., Haastert, B., Icks, A., Löwel, H., Meisinger, C., Holle, R., Giani, G. Diabetologia (2003) [Pubmed]
  33. Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Penninx, B.W., Guralnik, J.M., Ferrucci, L., Fried, L.P., Allen, R.H., Stabler, S.P. The American journal of psychiatry. (2000) [Pubmed]
  34. Prevalence of fatigue and chronic fatigue syndrome in a primary care practice. Bates, D.W., Schmitt, W., Buchwald, D., Ware, N.C., Lee, J., Thoyer, E., Kornish, R.J., Komaroff, A.L. Arch. Intern. Med. (1993) [Pubmed]
  35. High serum retinyl esters are not associated with reduced bone mineral density in the Third National Health And Nutrition Examination Survey, 1988-1994. Ballew, C., Galuska, D., Gillespie, C. J. Bone Miner. Res. (2001) [Pubmed]
  36. Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease. Phillips, D., Prentice, L., Upadhyaya, M., Lunt, P., Chamberlain, S., Roberts, D.F., McLachlan, S., Smith, B.R. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  37. CYP1A1 and GSTM1 polymorphisms and oral cancer risk. Park, J.Y., Muscat, J.E., Ren, Q., Schantz, S.P., Harwick, R.D., Stern, J.C., Pike, V., Richie, J.P., Lazarus, P. Cancer Epidemiol. Biomarkers Prev. (1997) [Pubmed]
  38. Multicenter study on TGPO autoantibody prevalence in various thyroid and non-thyroid diseases; relationships with thyroglobulin and thyroperoxidase autoantibody parameters. Estienne, V., Duthoit, C., Costanzo, V.D., Lejeune, P.J., Rotondi, M., Kornfeld, S., Finke, R., Lazarus, J.H., Feldt-Rasmussen, U., Franke, W.G., Smyth, P., D'Herbomez, M., Conte-Devolx, B., Persani, L., Carella, C., Jourdain, J.R., Izembart, M., Toubert, M.E., Pinchera, A., Weetman, A., Sapin, R., Carayon, P., Ruf, J. Eur. J. Endocrinol. (1999) [Pubmed]
  39. HLA-DPB1 polymorphism in patients with rheumatoid arthritis in Taiwan. Yen, J.H., Chen, J.R., Tsai, W.J., Tsai, J.J., Liu, H.W. J. Rheumatol. (1995) [Pubmed]
  40. Spurious hypertension in the obese patient. Effect of sphygmomanometer cuff size on prevalence of hypertension. Linfors, E.W., Feussner, J.R., Blessing, C.L., Starmer, C.F., Neelon, F.A., McKee, P.A. Arch. Intern. Med. (1984) [Pubmed]
  41. Bayesian comparison of cost-effectiveness of different clinical approaches to diagnose coronary artery disease. Patterson, R.E., Eng, C., Horowitz, S.F., Gorlin, R., Goldstein, S.R. J. Am. Coll. Cardiol. (1984) [Pubmed]
  42. Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study. Zeiger, R.S., Heller, S., Mellon, M.H., Forsythe, A.B., O'Connor, R.D., Hamburger, R.N., Schatz, M. J. Allergy Clin. Immunol. (1989) [Pubmed]
  43. Cumulative prevalence rates and corrected incidence rates of surgical sterilization among women in the United States, 1971--1978. Nolan, T.F., Ory, H.W., Layde, P.M., Hughes, J.M., Greenspan, J.R. Am. J. Epidemiol. (1982) [Pubmed]
  44. Differential prevalence of hepatitis C virus subtypes in healthy blood donors, patients on maintenance hemodialysis, and patients with hepatocellular carcinoma in Surabaya, Indonesia. Soetjipto, n.u.l.l., Handajani, R., Lusida, M.I., Darmadi, S., Adi, P., Soemarto, n.u.l.l., Ishido, S., Katayama, Y., Hotta, H. J. Clin. Microbiol. (1996) [Pubmed]
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