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Derk, C.T.

Chris T. Derk,

Transforming growth factor-beta (TGF-beta) and its role in the pathogenesis of systemic sclerosis: a novel target for therapy?

One of the growth factors that appear to play a crucial role in the pathogenesis of systemic sclerosis is TGF-beta. The three functionally and structurally similar human isoforms of TGF-beta play important roles in embryonic development, in the regulation of tissue repair following injury and in immune responses. Systemic sclerosis fibroblasts express increased levels of TGF-beta receptors on their surface which in turn results in increased signalimg of TGF-beta induced collagen gene expression. Some of the patents and intricate pathways that mediate the stimulation of collagen gene expression by TGF-beta have recently been described and a potential inhibition of these pathways may lead to novel therapeutic targets for systemic sclerosis.[1]

References

Transforming growth factor-beta (TGF-beta) and its role in the pathogenesis of systemic sclerosis: a novel target for therapy? Derk, C.T. Recent. Pat. Inflamm. Allergy. Drug. Discov (2007) [Pubmed]

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