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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments.

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.[1]

References

  1. Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments. Stow, N.D., Evans, V.C., Matthews, D.A. J. Gen. Virol. (2009) [Pubmed]
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