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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effect of Plasmodium berghei infection and chloroquine on the hepatic drug metabolizing system of mice.

The hepatic microsomal mixed-function oxidase (MFO) system was markedly impaired during Plasmodium berghei infection in mice. Cytochrome P-450 and other mono-oxygenases, viz. aniline hydroxylase, aminopyrine-N-demethylase and benzo(a)pyrene hydroxylase, were significantly decreased while microsomal heme showed a four-fold increase at peak parasitemia (greater than 50%). Oral treatment with chloroquine (16 mg kg-1 body wt for 4 days) of P. berghei-infected mice cleared the parasitemia within 72 h and almost normalized the altered levels of MFO indices, a week after cessation of treatment. The findings were further supported by the isoenzymic profile and drug-binding properties of terminal mono-oxygenase, cytochrome P-450.[1]

References

  1. Effect of Plasmodium berghei infection and chloroquine on the hepatic drug metabolizing system of mice. Srivastava, P., Tripathi, L.M., Puri, S.K., Dutta, G.P., Pandey, V.C. Int. J. Parasitol. (1991) [Pubmed]
 
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