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Gene Review

Cyp2c54  -  cytochrome P450, family 2, subfamily c,...

Mus musculus

Synonyms: CYPIIC54, Cytochrome P450 2C54, EG404195
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Disease relevance of Cyp2c54


Psychiatry related information on Cyp2c54

  • Individual differences in the levels of cytochrome P450 expression would be expected, and are known, to give rise to profound differences in toxicological response [6].

High impact information on Cyp2c54


Chemical compound and disease context of Cyp2c54


Biological context of Cyp2c54


Anatomical context of Cyp2c54


Associations of Cyp2c54 with chemical compounds


Physical interactions of Cyp2c54

  • The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene battery [26].
  • The murine Ah complex represents a 'cluster' of genes controlling the induction of numerous cytochrome P-450-mediated monooxygenase 'activities' by polycyclic aromatic compounds [27].
  • The effect of established inducers of microsomal P-450 caused complex changes in apparent rates of alpha-hydroxylation of NPYR which made interpretation of responses to inducer pretreatment difficult and suggested the participation of multiple cytochrome P-450 isozymes in the metabolism of NPYR [28].
  • The metabolites catalyzed by cytochrome P-450 in vitro were bound exclusively to a 50-kDa microsomal protein, even in the presence of albumin [29].
  • The influence of the major histocompatibility complex (H-2 in mouse) on induction of cytochrome P-450-dependent monooxygenase (P1-450) by the prototype polyaromatic hydrocarbon (PAH), beta-naphthoflavone, was investigated in C57BL/10 Sn (B10) recombinant congenic mice [30].

Enzymatic interactions of Cyp2c54


Regulatory relationships of Cyp2c54


Other interactions of Cyp2c54


Analytical, diagnostic and therapeutic context of Cyp2c54


  1. Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid. Crowe, D.O., Reiners, J.J., Nerland, D.E., Sonnenfeld, G. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Inhibitors of the cytochrome P-450 enzymes block the secretagogue-induced release of corticotropin in mouse pituitary tumor cells. Luini, A.G., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Functional analysis of the transcriptional promoter for the CYP1A1 gene. Jones, K.W., Whitlock, J.P. Mol. Cell. Biol. (1990) [Pubmed]
  4. Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice. Ghezzi, P., Bianchi, M., Gianera, L., Landolfo, S., Salmona, M. Cancer Res. (1985) [Pubmed]
  5. Modulation of hepatic mRNA levels after administration of lipopolysaccharide and diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP vaccine) to mice. Ansher, S.S., Thompson, W. Hepatology (1994) [Pubmed]
  6. Individuality in cytochrome P450 expression and its association with the nephrotoxic and carcinogenic effects of chemicals. Wolf, C.R. IARC Sci. Publ. (1991) [Pubmed]
  7. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Lindberg, R.L., Negishi, M. Nature (1989) [Pubmed]
  8. Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones. Haglund, L., Köhler, C., Haaparanta, T., Goldstein, M., Gustafsson, J.A. Nature (1984) [Pubmed]
  9. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs, C.J., Larkins, L.K., Price, R., Tullis, K.M., Miller, R.D., Robins, D.M. Genes Dev. (2003) [Pubmed]
  10. Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse. Pass, G.J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C.J., Wolf, C.R. Cancer Res. (2005) [Pubmed]
  11. In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A. Quintieri, L., Rosato, A., Napoli, E., Sola, F., Geroni, C., Floreani, M., Zanovello, P. Cancer Res. (2000) [Pubmed]
  12. Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice. Liu, Y., Yao, Z.X., Bendavid, C., Borgmeyer, C., Han, Z., Cavalli, L.R., Chan, W.Y., Folmer, J., Zirkin, B.R., Haddad, B.R., Gallicano, G.I., Papadopoulos, V. Mol. Endocrinol. (2005) [Pubmed]
  13. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Bessems, J.G., Vermeulen, N.P. Crit. Rev. Toxicol. (2001) [Pubmed]
  14. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Gu, J., Cui, H., Behr, M., Zhang, L., Zhang, Q.Y., Yang, W., Hinson, J.A., Ding, X. Mol. Pharmacol. (2005) [Pubmed]
  15. Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Goetz, A.K., Bao, W., Ren, H., Schmid, J.E., Tully, D.B., Wood, C., Rockett, J.C., Narotsky, M.G., Sun, G., Lambert, G.R., Thai, S.F., Wolf, D.C., Nesnow, S., Dix, D.J. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  16. Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics. Burt, R.K., Thorgeirsson, S.S. J. Natl. Cancer Inst. (1988) [Pubmed]
  17. The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein. Wilhelmsson, A., Cuthill, S., Denis, M., Wikström, A.C., Gustafsson, J.A., Poellinger, L. EMBO J. (1990) [Pubmed]
  18. Membrane-bound redox proteins of the murine Friend virus-induced erythroleukemia cell. Slaughter, S.R., Hultquist, D.E. J. Cell Biol. (1979) [Pubmed]
  19. Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells. Battula, N., Sagara, J., Gelboin, H.V. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  20. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Burger, H.J., Schuetz, J.D., Schuetz, E.G., Guzelian, P.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine. Shen, Z., Wells, R.L., Liu, J., Elkind, M.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Modulation of constitutive cytochrome P-450 expression in vivo and in vitro in murine keratinocytes as a function of differentiation and extracellular Ca2+ concentration. Reiners, J.J., Cantu, A.R., Pavone, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  23. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Xie, W., Barwick, J.L., Simon, C.M., Pierce, A.M., Safe, S., Blumberg, B., Guzelian, P.S., Evans, R.M. Genes Dev. (2000) [Pubmed]
  24. Influence of inducers of monooxygenases on cytotoxic efficiency of ellipticine on leukemia L1210 cells. Lesca, P., Monsarrat, B., Cros, S., Paoletti, C. J. Natl. Cancer Inst. (1981) [Pubmed]
  25. Alterations in microsomal metabolism of benzo[a]pyrene in mice fed butylated hydroxyanisole. Speier, J.L., Wattenberg, L.W. J. Natl. Cancer Inst. (1975) [Pubmed]
  26. Constitutive activation of the aromatic hydrocarbon receptor. Chang, C.Y., Puga, A. Mol. Cell. Biol. (1998) [Pubmed]
  27. Ontogenetic expression of regulatory and structural gene products associated with the Ah locus. Comparison of rat, mouse, rabbit and Sigmoden hispedis. Kahl, G.F., Friederici, D.E., Bigelow, S.W., Okey, A.B., Nebert, D.W. Developmental pharmacology and therapeutics. (1980) [Pubmed]
  28. Reconstitution of rabbit liver microsomal N-nitrosopyrrolidine alpha-hydroxylase activity. McCoy, G.D., Koop, D.R. Cancer Res. (1988) [Pubmed]
  29. Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Hargus, S.J., Amouzedeh, H.R., Pumford, N.R., Myers, T.G., McCoy, S.C., Pohl, L.R. Chem. Res. Toxicol. (1994) [Pubmed]
  30. Differences in H-2 recombinant mice in the beta-naphthoflavone inducibility of the mixed function monooxygenase, P1-450. Koizumi, A., Walford, R.L., Hasegawa, L. Immunogenetics (1987) [Pubmed]
  31. Subacute cocaine treatment changes expression of mouse liver cytochrome P450 isoforms. Powers, J.F., Shuster, L. Pharmacology (1999) [Pubmed]
  32. Monoclonal antibody-directed phenotyping of cytochrome P-450-dependent aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase in mammalian tissues. Fujino, T., West, D., Park, S.S., Gelboin, H.V. J. Biol. Chem. (1984) [Pubmed]
  33. Müllerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation. Laurich, V.M., Trbovich, A.M., O'Neill, F.H., Houk, C.P., Sluss, P.M., Payne, A.H., Donahoe, P.K., Teixeira, J. Endocrinology (2002) [Pubmed]
  34. The aryl hydrocarbon receptor: studies using the AHR-null mice. Gonzalez, F.J., Fernandez-Salguero, P. Drug Metab. Dispos. (1998) [Pubmed]
  35. Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Jeffery, B., Choudhury, A.I., Horley, N., Bruce, M., Tomlinson, S.R., Roberts, R.A., Gray, T.J., Barrett, D.A., Shaw, P.N., Kendall, D., Bell, D.R. Arch. Biochem. Biophys. (2004) [Pubmed]
  36. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Ikeda, Y., Lala, D.S., Luo, X., Kim, E., Moisan, M.P., Parker, K.L. Mol. Endocrinol. (1993) [Pubmed]
  37. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Stulnig, T.M., Steffensen, K.R., Gao, H., Reimers, M., Dahlman-Wright, K., Schuster, G.U., Gustafsson, J.A. Mol. Pharmacol. (2002) [Pubmed]
  38. Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Koubova, J., Menke, D.B., Zhou, Q., Capel, B., Griswold, M.D., Page, D.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  39. Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent. Siewert, E., Bort, R., Kluge, R., Heinrich, P.C., Castell, J., Jover, R. Hepatology (2000) [Pubmed]
  40. Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. Savas, U., Bhattacharyya, K.K., Christou, M., Alexander, D.L., Jefcoate, C.R. J. Biol. Chem. (1994) [Pubmed]
  41. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. Schwarz, M., Lund, E.G., Lathe, R., Björkhem, I., Russell, D.W. J. Biol. Chem. (1997) [Pubmed]
  42. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. Fraser, D.J., Zumsteg, A., Meyer, U.A. J. Biol. Chem. (2003) [Pubmed]
  43. Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization. Mitsuda, M., Iwasaki, M., Asahi, S. J. Biochem. (2006) [Pubmed]
  44. Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes. Thomas, P.E., Reik, L.M., Ryan, D.E., Levin, W. J. Biol. Chem. (1984) [Pubmed]
  45. Testosterone inhibits cAMP-induced de Novo synthesis of Leydig cell cytochrome P-450(17 alpha) by an androgen receptor-mediated mechanism. Hales, D.B., Sha, L.L., Payne, A.H. J. Biol. Chem. (1987) [Pubmed]
  46. Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus. Sipowicz, M.A., Chomarat, P., Diwan, B.A., Anver, M.A., Awasthi, Y.C., Ward, J.M., Rice, J.M., Kasprzak, K.S., Wild, C.P., Anderson, L.M. Am. J. Pathol. (1997) [Pubmed]
  47. Isolation and characterization of a cytochrome P-450 from rat kidney mitochondria that catalyzes the 24-hydroxylation of 25-hydroxyvitamin D3. Ohyama, Y., Okuda, K. J. Biol. Chem. (1991) [Pubmed]
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