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Cyp2c54  -  cytochrome P450, family 2, subfamily c,...

Mus musculus

Synonyms: CYPIIC54, Cytochrome P450 2C54, EG404195
 
 
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Disease relevance of Cyp2c54

 

Psychiatry related information on Cyp2c54

  • Individual differences in the levels of cytochrome P450 expression would be expected, and are known, to give rise to profound differences in toxicological response [6].
 

High impact information on Cyp2c54

 

Chemical compound and disease context of Cyp2c54

 

Biological context of Cyp2c54

 

Anatomical context of Cyp2c54

 

Associations of Cyp2c54 with chemical compounds

 

Physical interactions of Cyp2c54

  • The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene battery [26].
  • The murine Ah complex represents a 'cluster' of genes controlling the induction of numerous cytochrome P-450-mediated monooxygenase 'activities' by polycyclic aromatic compounds [27].
  • The effect of established inducers of microsomal P-450 caused complex changes in apparent rates of alpha-hydroxylation of NPYR which made interpretation of responses to inducer pretreatment difficult and suggested the participation of multiple cytochrome P-450 isozymes in the metabolism of NPYR [28].
  • The metabolites catalyzed by cytochrome P-450 in vitro were bound exclusively to a 50-kDa microsomal protein, even in the presence of albumin [29].
  • The influence of the major histocompatibility complex (H-2 in mouse) on induction of cytochrome P-450-dependent monooxygenase (P1-450) by the prototype polyaromatic hydrocarbon (PAH), beta-naphthoflavone, was investigated in C57BL/10 Sn (B10) recombinant congenic mice [30].
 

Enzymatic interactions of Cyp2c54

 

Regulatory relationships of Cyp2c54

 

Other interactions of Cyp2c54

 

Analytical, diagnostic and therapeutic context of Cyp2c54

References

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  4. Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice. Ghezzi, P., Bianchi, M., Gianera, L., Landolfo, S., Salmona, M. Cancer Res. (1985) [Pubmed]
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  6. Individuality in cytochrome P450 expression and its association with the nephrotoxic and carcinogenic effects of chemicals. Wolf, C.R. IARC Sci. Publ. (1991) [Pubmed]
  7. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Lindberg, R.L., Negishi, M. Nature (1989) [Pubmed]
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  17. The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein. Wilhelmsson, A., Cuthill, S., Denis, M., Wikström, A.C., Gustafsson, J.A., Poellinger, L. EMBO J. (1990) [Pubmed]
  18. Membrane-bound redox proteins of the murine Friend virus-induced erythroleukemia cell. Slaughter, S.R., Hultquist, D.E. J. Cell Biol. (1979) [Pubmed]
  19. Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells. Battula, N., Sagara, J., Gelboin, H.V. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  20. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Burger, H.J., Schuetz, J.D., Schuetz, E.G., Guzelian, P.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine. Shen, Z., Wells, R.L., Liu, J., Elkind, M.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Modulation of constitutive cytochrome P-450 expression in vivo and in vitro in murine keratinocytes as a function of differentiation and extracellular Ca2+ concentration. Reiners, J.J., Cantu, A.R., Pavone, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  23. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Xie, W., Barwick, J.L., Simon, C.M., Pierce, A.M., Safe, S., Blumberg, B., Guzelian, P.S., Evans, R.M. Genes Dev. (2000) [Pubmed]
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  25. Alterations in microsomal metabolism of benzo[a]pyrene in mice fed butylated hydroxyanisole. Speier, J.L., Wattenberg, L.W. J. Natl. Cancer Inst. (1975) [Pubmed]
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  28. Reconstitution of rabbit liver microsomal N-nitrosopyrrolidine alpha-hydroxylase activity. McCoy, G.D., Koop, D.R. Cancer Res. (1988) [Pubmed]
  29. Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Hargus, S.J., Amouzedeh, H.R., Pumford, N.R., Myers, T.G., McCoy, S.C., Pohl, L.R. Chem. Res. Toxicol. (1994) [Pubmed]
  30. Differences in H-2 recombinant mice in the beta-naphthoflavone inducibility of the mixed function monooxygenase, P1-450. Koizumi, A., Walford, R.L., Hasegawa, L. Immunogenetics (1987) [Pubmed]
  31. Subacute cocaine treatment changes expression of mouse liver cytochrome P450 isoforms. Powers, J.F., Shuster, L. Pharmacology (1999) [Pubmed]
  32. Monoclonal antibody-directed phenotyping of cytochrome P-450-dependent aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase in mammalian tissues. Fujino, T., West, D., Park, S.S., Gelboin, H.V. J. Biol. Chem. (1984) [Pubmed]
  33. Müllerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation. Laurich, V.M., Trbovich, A.M., O'Neill, F.H., Houk, C.P., Sluss, P.M., Payne, A.H., Donahoe, P.K., Teixeira, J. Endocrinology (2002) [Pubmed]
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  39. Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent. Siewert, E., Bort, R., Kluge, R., Heinrich, P.C., Castell, J., Jover, R. Hepatology (2000) [Pubmed]
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  41. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. Schwarz, M., Lund, E.G., Lathe, R., Björkhem, I., Russell, D.W. J. Biol. Chem. (1997) [Pubmed]
  42. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. Fraser, D.J., Zumsteg, A., Meyer, U.A. J. Biol. Chem. (2003) [Pubmed]
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