Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Galoyan, A.A. et al.

A.A. Galoyan, L.I. Korochkin, E.J. Rybalkina, G.V. Pavlova, I.N. Saburina, E.I. Zaraiski, N.A. Galoyan, T.K. Davtyan, K.B. Bezirganyan, A.V. Revishchin,

Hypothalamic proline-rich polypeptide enhances bone marrow colony-forming cell proliferation and stromal progenitor cell differentiation.

The AGAPEPAEPAQPGVY proline-rich peptide (PRP-1) was isolated from neurosecretory granules of the bovine neurohypophysis; it is produced by N. supraopticus and N. paraventricularis. It has been shown that PRP-1 has many potentially beneficial biological effects, including immunoregulatory, hematopoietic, antimicrobial, and antineurodegenerative properties. Here we showed that PRP increased colony-forming cell (CFC) proliferation in rat bone marrow (BM) cells in vivo. In PRP-treated rat BM, the CFU number at day 7 and day 14 was considerably increased in comparison with untreated rat BM and no difference was found at day 21 and day 28. The related peptide [arg8]vasopressin did not reveal CFC proliferation. PRP failed to farther increase CFC proliferation in vitro in BM obtained from PRP-treated or untreated rats. After 3-4 days of human BM stromal cell cultivation in the presence of 2-20 microg/ml PRP the appearance of cells expressing CD15, CD10, CD11a, CD11b, CD3, CD4, and CD16 surface antigens did not differ from the untreated cells. PRP increased the appearance of CD14-positive cells upon 3-4-day incubation with both adult and fetal BM stromal cells. Our results suggest a previously undescribed role for the hypothalamic peptide within neurosecretory hypothalamus-bone marrow humoral axis, because PRP enhances BM colony-forming cell proliferation and stromal cell differentiation.[1]

References

Hypothalamic proline-rich polypeptide enhances bone marrow colony-forming cell proliferation and stromal progenitor cell differentiation. Galoyan, A.A., Korochkin, L.I., Rybalkina, E.J., Pavlova, G.V., Saburina, I.N., Zaraiski, E.I., Galoyan, N.A., Davtyan, T.K., Bezirganyan, K.B., Revishchin, A.V. Cell. Transplant (2008) [Pubmed]

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