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Zee, R.Y. et al.

Robert Y. L. Zee, Sherri E. Michaud, Soren Germer, Paul M. Ridker,

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach.

BACKGROUND: Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce. METHODS: Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol, among 337 white males who subsequently developed an incident myocardial infarction (MI), and among an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls). RESULTS: The mean follow-up time since randomization was 3.85 y. The T/S ratio was inversely correlated with age in the controls (R=-0.114; p=0.036). The log(e)-transformed T/S ratios were significantly smaller in the MI cases (3.41+/-0.63) than the MI controls (3.52+/-0.78) (p=0.01). In a multi-variable adjusted analysis, decreased T/S ratio was significantly associated with risk of MI (odds ratio=1.621; 95%CI=1.140-2.304; p=0.007). CONCLUSIONS: The present investigation has shown an association of telomere length shortening with increased risk of incident myocardial infarction, further suggesting the importance of telomere biology in atherogenesis.[1]

References

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach. Zee, R.Y., Michaud, S.E., Germer, S., Ridker, P.M. Clin. Chim. Acta (2009) [Pubmed]

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