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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cystic fibrosis in the population of Reunion Island.

The frequencies of the delta F 508 mutation and haplotypes linked to the cystic fibrosis ( CF) gene and detected with DNA probes XV-2C and KM-19 have been studied in the population of Reunion Island, a French province located in the Indian Ocean. The deletion was present in 41.3% of CF chromosomes, whereas this proportion is about 70% in the French population. The delta F 508 mutation was associated with the haplotype B defined by the DNA markers XV-2C (allele 1) and KM-19 (allele 2) in 76.4% of CF chromosomes, while this proportion is over 90% in the French population. Founder effect, genetic drift and admixture can explain these differences.[1]

References

  1. Cystic fibrosis in the population of Reunion Island. Hillaire, D., Chomel, J.C., Lesure, F., Renouil, M., Musenger, C., Pierson, F., Berthelon, M., Lenoir, G., Gérard, G., Bois, E. Ann. Genet. (1991) [Pubmed]
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