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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.

Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).[1]

References

  1. A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor. Reddy, G.R., Ueda, N., Hada, T., Sackeyfio, A.C., Yamamoto, S., Hano, Y., Aida, M., Nomura, T. Biochem. Pharmacol. (1991) [Pubmed]
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