- Fructose-1,6-bisphosphate, when given immediately before reoxygenation, or before injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig. LeBlanc, M.H., Farias, L.A., Evans, O.B., Vig, V., Smith, E.E., Markov, A.K. Crit. Care Med. (1991)