- Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic-pharmacodynamic analysis from the IELSG no. 20 trial. Joerger, M., Huitema, A.D., Krähenbühl, S., Schellens, J.H., Cerny, T., Reni, M., Zucca, E., Cavalli, F., Ferreri, A.J. Br. J. Cancer (2010)