Nucleotide sequence of cDNA to the rinderpest virus mRNA encoding the nucleocapsid protein.
The full-length cDNA corresponding to the mRNA encoding the nucleocapsid protein ( NP) of rinderpest virus (RV) was cloned and its complete nucleotide sequence was determined. The gene of RV- NP was composed of 1683 nucleotides and contained a single large open reading frame, which is capable of encoding a protein of 525 amino acids with a molecular weight of 58,241 Da. The nucleotide sequence and predicted amino acid sequence were compared with those of measles virus (MV) and canine distemper virus (CDV). The nucleotide sequence of the coding region of RV- NP (53-1630) revealed a homology of 68.1% and 63.0% with MV and CDV- NP, respectively. Relatively moderate homologies of 68.7% (MV) and 64.3% (CDV) were found at nucleotides 53-592. The highest homology of 75.3-74.3% was equally present between RV and both MV and CDV in the middle region at nucleotides 593-1312. The homologies of the predicted amino acids in this region were 88.3% (MV) and 86.3% (CDV). Relatively low (MV) or little (CDV) homology was detected in the last 318 nucleotides toward the 3' terminus (1313-1630). The predicted secondary structures of amino acids at the C terminus differed between the three viruses.[1]References
- Nucleotide sequence of cDNA to the rinderpest virus mRNA encoding the nucleocapsid protein. Kamata, H., Tsukiyama, K., Sugiyama, M., Kamata, Y., Yoshikawa, Y., Yamanouchi, K. Virus Genes (1991) [Pubmed]
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