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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.[1]

References

  1. Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. Hansen, J.E., Witzke, N.M., Nielsen, C., Mathiesen, L.R., Teglbjaerg, L.S., Nielsen, C.M., Nielsen, J.O. Antiviral Res. (1990) [Pubmed]
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