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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis and in vitro activity of new cephalosporin derivatives containing a benzoxazolone ring.

New cephalosporin derivatives containing a benzoxazolone ring in the side acylamino chain are synthesized using chlorides of non-substituted and halogen substituted (2-benzoxazolone-3-yl) acetic acids for the acylation of the 7-aminodesacetoxy-cephalosporanic acid and 7-amino-cephalosporanic acid amino group. Some of these new compounds exhibit a biological activity higher than that of cephalexin and cephazolin against clinical strains of Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus group A and B.[1]

References

  1. Synthesis and in vitro activity of new cephalosporin derivatives containing a benzoxazolone ring. Kalcheva, V., Mincheva, Z., Andreeva, P. Arzneimittel-Forschung. (1990) [Pubmed]
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