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Chemical Compound Review

Totacef     (6R,7S)-3-[(5-methyl-1,3,4- thiadiazol-2...

Synonyms: Cefazina, Elzogram, Firmacef, Cefamezin, Liviclina, ...
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Disease relevance of Cephazolin


Psychiatry related information on Cephazolin

  • The anticonvulsant activity of avermectin B (AVM) was studied after systemic administration in DBA/2 mice (seizures induced by sound) and rats (seizures induced by pentylenetetrazol, cephazolin and maximal electroshock test) [6].

High impact information on Cephazolin


Chemical compound and disease context of Cephazolin


Biological context of Cephazolin


Anatomical context of Cephazolin


Associations of Cephazolin with other chemical compounds


Gene context of Cephazolin

  • Beta-lactamase resistance of cephazolin and other cephalosporins [29].

Analytical, diagnostic and therapeutic context of Cephazolin


  1. Alafosfalin, a new inhibitor of cell wall biosynthesis: in vitro activity against urinary isolates in Japan and potentiation with beta-lactams. Maruyama, H.B., Arisawa, M., Sawada, T. Antimicrob. Agents Chemother. (1979) [Pubmed]
  2. Are bile bacteria relevant to septic complications following biliary surgery? Willis, R.G., Lawson, W.C., Hoare, E.M., Kingston, R.D., Sykes, P.A. The British journal of surgery. (1984) [Pubmed]
  3. Antibiotic prophylaxis for ERCP: a comparison of oral ciprofloxacin with intravenous cephazolin in the prophylaxis of high-risk patients. Davis, A.J., Kolios, G., Alveyn, C.G., Robertson, D.A. Aliment. Pharmacol. Ther. (1998) [Pubmed]
  4. Pseudomembranous colitis associated with cephazolin therapy. Fee, H.J., Ament, M.E., Holmes, E.C. Am. J. Surg. (1977) [Pubmed]
  5. Occult Streptococcus pyogenes in cellulitis: demonstration by immunofluorescence. Shelley, W.B., Talanin, N., Shelley, E.D., Freimer, E.H. Br. J. Dermatol. (1995) [Pubmed]
  6. Anticonvulsant effects of avermectin in DBA/2 mice and rat. Ammendola, D., De Sarro, A., De Sarro, G.B., Germanà, G., Naccari, F., Rotiroti, D. Experimental biology. (1988) [Pubmed]
  7. Comparison of the antimicrobial prophylactic efficacy of cefotaxime and cephazolin in obstetric and gynaecological surgery. A randomised multicentre study. Periti, P., Mazzei, T., Orlandini, F., Mini, E. Drugs (1988) [Pubmed]
  8. Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Campoli-Richards, D.M., Lackner, T.E., Monk, J.P. Drugs (1987) [Pubmed]
  9. Pharmacokinetics of cefoperazone: a review. Craig, W.A., Gerber, A.U. Drugs (1981) [Pubmed]
  10. Clinical experience with cefoperazone in biliary tract infections. Mashimo, K. Drugs (1981) [Pubmed]
  11. Prospective randomized trial of systemic antibiotics in patients undergoing liver resection. Wu, C.C., Yeh, D.C., Lin, M.C., Liu, T.J., P'eng, F.K. The British journal of surgery. (1998) [Pubmed]
  12. Randomised study of prophylactic parenteral sulbactam/ampicillin and cephazolin in biliary surgery: significant benefit in jaundiced patients. Morris, D.L., Jones, J.A., Harrison, J.D., Andrews, G.I., Phillips, R.J., Slack, R.C. J. Hosp. Infect. (1989) [Pubmed]
  13. A comparison of cefotetan and cephazolin for prophylaxis against wound infection after elective cholecystectomy. Drumm, J., Donovan, I.A., Wise, R. J. Hosp. Infect. (1985) [Pubmed]
  14. Prevention of wound infection in elective colorectal resections by preoperative cephazolin with and without metronidazole. McDermott, F.T., Polglase, A.L., Johnson, W.R., Hughes, E.S. The Australian and New Zealand journal of surgery. (1981) [Pubmed]
  15. Comparative biliary concentrations of cephazolin and cephalothin in patients with biliary tract disease. Madhavan, T., Block, M., Quinn, E.L., Cox, F., Fisher, E.J., Burch, K.H., Haas, E.J. Scottish medical journal. (1976) [Pubmed]
  16. Preventing and treating discitis: cephazolin penetration in ovine lumbar intervertebral disc. Walters, R., Rahmat, R., Fraser, R., Moore, R. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. (2006) [Pubmed]
  17. Latamoxef: single agent prophylaxis in colorectal surgery. Thomas, W.E., Cooper, M.J., Holt, A., Reeves, D. J. Antimicrob. Chemother. (1985) [Pubmed]
  18. Effect of lipid fluidity upon the activity and structure of the 39 kDa porin from Enterobacter cloacae 908S. Ghosh, R., Aggeler, R. FEBS Lett. (1987) [Pubmed]
  19. Septic abortion associated with Campylobacter fetus subspecies fetus infection: case report and review of the literature. Sauerwein, R.W., Bisseling, J., Horrevorts, A.M. Infection (1993) [Pubmed]
  20. Proceedings: Cephazolin in obstetrics. Hannay, W.T., Sharp, F., Parman, M.G., McAllister, T.A. Scottish medical journal. (1975) [Pubmed]
  21. Clinical bacteriology of cephazolin. McAllister, T.A., Tait, S.C., Perman, M.G., Park, A.C. Scottish medical journal. (1976) [Pubmed]
  22. Intracameral cefazolin as prophylaxis against endophthalmitis in cataract surgery. Romero, P., Méndez, I., Salvat, M., Fernández, J., Almena, M. Journal of cataract and refractive surgery. (2006) [Pubmed]
  23. Clinical, microbiological, and economic benefit of a change in antibiotic prophylaxis for cardiac surgery. Spelman, D., Harrington, G., Russo, P., Wesselingh, S. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2002) [Pubmed]
  24. Assessment of the morbidity and value of prophylactic cephazolin sodium in urinary tract instrumentation in out-patients. Hart, A.J., Miles, R.S., Varnam, D.J., Edmond, P. Current medical research and opinion. (1980) [Pubmed]
  25. The penetrability of cephazolin into the subcutaneous fat and skeletal muscle of ischaemic lower limbs with atherosclerotic disease. Kester, R.C., Ramsden, C.H., Matharu, S.S. Current medical research and opinion. (1979) [Pubmed]
  26. Behaviour of beta-lactamase-positive and -negative Staphylococcus aureus isolates in susceptibility tests with piperacillin/tazobactam and other beta-lactam/beta-lactamase inhibitor combinations. Bonfiglio, G., Livermore, D.M. J. Antimicrob. Chemother. (1993) [Pubmed]
  27. Status epilepticus following enflurane anaesthesia. Nicoll, J.M. Anaesthesia. (1986) [Pubmed]
  28. Effects of interleukin-2 on various models of experimental epilepsy in DBA/2 mice. De Sarro, G., Rotiroti, D., Audino, M.G., Gratteri, S., Nisticó, G. Neuroimmunomodulation (1994) [Pubmed]
  29. Beta-lactamase resistance of cephazolin and other cephalosporins. Goodwin, C.S., Hill, J.P. Scottish medical journal. (1976) [Pubmed]
  30. Accidental epidural cephazolin injection: safeguards for patient-controlled analgesia. Kopacz, D.J., Slover, R.B. Anesthesiology (1990) [Pubmed]
  31. Intracerebral haemorrhage caused by cefazoline-induced hypoprothrombinaemia in a renal transplant recipient. Kuypers, D.R., Claes, K. Nephrol. Dial. Transplant. (2002) [Pubmed]
  32. Cephazolin treatment of pneumonia in the elderly. Castleton, B., Goodwin, C.S., Stirling, J., Pitcher-Wilmott, R., Elton, A. Age and ageing. (1976) [Pubmed]
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