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Mach, R.H. et al.

Robert H. Mach, Zhude Tu, Jinbin Xu, Shihong Li, Lynne A. Jones, Michelle Taylor, Robert R. Luedtke, Colin P. Derdeyn, Joel S. Perlmutter, Mark A. Mintun,

Endogenous dopamine (DA) competes with the binding of a radiolabeled D(3) receptor partial agonist in vivo: A positron emission tomography study.

A series of microPET imaging studies were conducted in anesthetized rhesus monkeys using the dopamine D(3) -selective partial agonist, [(18) F]5. There was variable uptake in regions of brain known to express a high density of D(3) receptors under baseline conditions. Pretreatment with lorazepam (1 mg/kg, i.v. 30 min) to reduce endogenous dopamine activity before tracer injection resulted in a dramatic increase in uptake in the caudate, putamen, and thalamus, and an increase in the binding potential (BP) values, a measure of D(3) receptor binding in vivo. These data indicate that there is a high level of competition between [(18) F]5 and endogenous dopamine for D(3) receptors in vivo. Synapse 2011. © 2011 Wiley-Liss, Inc.[1]

References

Endogenous dopamine (DA) competes with the binding of a radiolabeled D(3) receptor partial agonist in vivo: A positron emission tomography study. Mach, R.H., Tu, Z., Xu, J., Li, S., Jones, L.A., Taylor, M., Luedtke, R.R., Derdeyn, C.P., Perlmutter, J.S., Mintun, M.A. Synapse (2011) [Pubmed]

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