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Takeuchi, K. et al.

Kengo Takeuchi, Manabu Soda, Yuki Togashi, Yasunori Ota, Yasunobu Sekiguchi, Satoko Hatano, Reimi Asaka, Masaaki Noguchi, Hiroyuki Mano,

Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma.

ALK-positive large B-cell lymphoma is a rare subtype of lymphoma, and most cases follow an aggressive clinical course with a poor prognosis. We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the presence of a novel ALK fusion; this led to the identification of SQSTM1-ALK. SQSTM1 is an ubiquitin binding protein that is associated with oxidative stress, cell signaling, and autophagy. We showed transforming activities of SQSTM1-ALK with a focus formation assay and an in vivo tumorigenicity assay using 3T3 fibroblasts infected with a recombinant retrovirus encoding SQSTM1-ALK. ALK-inhibitor therapies are promising for treating ALK-positive large B-cell lymphoma, especially for refractory cases. SQSTM1-ALK may be a rare fusion, but our data provide novel biological insights and serve as a key for the accurate diagnosis of this rare lymphoma.[1]

References

Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. Takeuchi, K., Soda, M., Togashi, Y., Ota, Y., Sekiguchi, Y., Hatano, S., Asaka, R., Noguchi, M., Mano, H. Haematologica (2011) [Pubmed]

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