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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Proteomic biomarkers for overall and progression-free survival in ovarian cancer patients.

PURPOSE: To determine if the level of apolipoprotein A1, hepcidin, transferrin, inter-α trypsin IV internal fragment, transthyretin (TT), connective-tissue activating protein 3 (CTAP3), serum amyloid A1, β-2 microglobulin (B2M) might have impact on overall and progression-free survival for ovarian cancer (OC) patients. EXPERIMENTAL DESIGN: Serum from 150 OC patients was tested using SELDI-TOF-MS. RESULTS: A proteomic prognostic index (xb-pro) was constructed using the regression coefficients based on inter-α trypsin IV internal fragment, B2M and TT. A multivariable Cox survival analysis including the xb-pro index showed that xb-pro (p<0.0001, HR=2.50, 95% CI: 1.65-3.79), residual tumor after primary surgery (p=0.0005), age (p=0.01) and chemotherapy (p=0.0002) are of independent prognostic value for overall survival. International Federation of Gynecology and Obstetrics stage, performance status, histological type of tumor and serum CA125 were found of no independent value. A proteomic index (xb-pfs) based on B2M and CTAP3 was found to predict progression-free survival (xb-pfs: p=0.008, HR=1.77, 95% CI: 1.17-2.70 together with type of surgery, age and chemotherapy. CONCLUSIONS AND CLINICAL RELEVANCE: We found an index with three proteomic biomarkers (xb-pro) to be of independent prognostic value for overall survival and an index with two proteomic biomarkers (xb-pfs) with evidence of independent prognostic value for progression-free survival.[1]

References

  1. Proteomic biomarkers for overall and progression-free survival in ovarian cancer patients. Høgdall, E., Fung, E.T., Christensen, I.J., Yip, C., Nedergaard, L., Engelholm, S.A., Risum, S., Petri, A.L., Lundvall, L., Lomas, L., Høgdall, C. Proteomics. Clin. Appl (2010) [Pubmed]
 
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