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Disease relevance of Obstetrics

  • We updated 152 cases of epithelial ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) stages I through III, treated at the Stanford Medical Center (Stanford, Calif) with irradiation as the only postoperative therapy [1].
  • RESULTS: Increased pretreatment SCC-ag levels correlated strongly with unfavorable clinicopathologic characteristics (International Federation of Gynecology and Obstetrics [FIGO] stages IB to IV [P < or = .00005]; stages IB and IIA: tumor size [P = .0236], deep stromal infiltration [P = .00009], and lymph node metastasis [P = .0001]) [2].
  • Long-acting prostaglandin analogues are currently used in obstetrics and are being tested in the treatment of thrombosis, inflammation, and excessive gastric acid secretion [3].
  • After adjusting for age, International Federation of Gynecology and Obstetrics (FIGO) stage, the presence of residual tumor, and the presence of invasive implants, patients whose tumors overexpressed p53 had a 4-fold increased risk of progression/ recurrence [4].
  • Concerning relation to Federation for International Gynaecology and Obstetrics (FIGO) grade, claudin 3, but not claudin 4, was significantly increased in moderately, poorly and undifferentiated adenocarcinomas compared to well-differentiated and borderline-type tumours [5].

Psychiatry related information on Obstetrics


High impact information on Obstetrics


Chemical compound and disease context of Obstetrics


Biological context of Obstetrics


Anatomical context of Obstetrics

  • The administration of dexamethasone to 7-day-old rats resulted in significant depletion of glucocorticoid receptors from the cytosol of the brain in a dose-dependent manner, beginning with the dose of 0.04 mg/kg (s.c.), i.e. a dose one order lower than the clinical dose used in obstetrics (0.4-0.5 mg/kg) [25].
  • SETTING: Department of Obstetrics and Gynecology, School of Medicine, the University of Tokushima, Japan. PATIENT(S): Semen were obtained from three fertile healthy volunteers [26].
  • By screening sera obtained from 5015 pregnant women under the care of 9 gynecology/obstetrics departments of hospitals or clinics in Nagasaki City and its surrounding areas, 187 were found to be positive for antibody against adult T-cell leukemia-associated antigen (ATLA) [27].
  • Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845 [28].
  • A total of 846 Pap smears in women post-treated for genital organ diseases by operation and radiation (1.7% of all those made) at the Cytological Unit, Department of Obstetrics & Gynaecology, Faculty of Medicine, Siriraj Hospital between April 4, 1983 and July 4, 1984, were examined [29].

Associations of Obstetrics with chemical compounds


Gene context of Obstetrics

  • We investigated iNOS and COX-2 expression in relation to clinical outcome in 78 International Federation of Gynecology and Obstetrics (FIGO) stage III ovarian serous carcinoma with a low grade of differentiation (G3) [35].
  • Although high antibody levels were associated with greater survival in ovarian cancer (P=0.015), multivariate regression analysis showed that this was not a significant independent prognostic indicator after consideration of the International Federation of Gynaecology and Obstetrics (FIGO) stage, histological type, serum MUC1 levels and age [36].
  • Reduced PTEN expression in adenocarcinomas did not correlate with International Federation of Obstetrics and Gynecology (FIGO) stage [37].
  • Cases with higher International Federation of Gynecology and Obstetrics stages (IIb-IVa) exhibited stronger expression of CA IX (P = 0.035) and CA IX expression tended to be more prevalent in node-positive patients (P = 0.051) [38].
  • The immunoexpression pattern of E-cadherin was associated with International Federation of Gynaecology and Obstetrics (FIGO) staging (P = 0.043), histologic subtype (P = 0.001), peritoneal metastasis (P = 0.006), and residual tumor (P = 0.036) [39].

Analytical, diagnostic and therapeutic context of Obstetrics


  1. Postoperative radiation therapy for epithelial ovarian cancer: the curative role based on a 24-year experience. Martinez, A., Schray, M.F., Howes, A.E., Bagshaw, M.A. J. Clin. Oncol. (1985) [Pubmed]
  2. Pretreatment serum squamous cell carcinoma antigen: a newly identified prognostic factor in early-stage cervical carcinoma. Duk, J.M., Groenier, K.H., de Bruijn, H.W., Hollema, H., ten Hoor, K.A., van der Zee, A.G., Aalders, J.G. J. Clin. Oncol. (1996) [Pubmed]
  3. Biologic importance of arachidonic acid. Ramwell, P.W. Arch. Intern. Med. (1981) [Pubmed]
  4. Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors. Gershenson, D.M., Deavers, M., Diaz, S., Tortolero-Luna, G., Miller, B.E., Bast, R.C., Mills, G.B., Silva, E.G. Clin. Cancer Res. (1999) [Pubmed]
  5. Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Zhu, Y., Brännström, M., Janson, P.O., Sundfeldt, K. Int. J. Cancer (2006) [Pubmed]
  6. Effect of long-term naltrexone treatment on endocrine profile, clinical features, and insulin sensitivity in obese women with polycystic ovary syndrome. Fruzzetti, F., Bersi, C., Parrini, D., Ricci, C., Genazzani, A.R. Fertil. Steril. (2002) [Pubmed]
  7. Effect of sleep deprivation on medical resident and student cognitive function: A prospective study. Halbach, M.M., Spann, C.O., Egan, G. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  8. Rape, torture, and traumatization of Bosnian and Croatian women: psychological sequelae. Kozaric-Kovacic, D., Folnegovic-Smalc, V., Skrinjaric, J., Szajnberg, N.M., Marusic, A. The American journal of orthopsychiatry. (1995) [Pubmed]
  9. Discussion: severe mental retardation and cancer among atomic bomb survivors exposed in utero. Miller, R.W. Teratology (1999) [Pubmed]
  10. The impact of early specialization on the clinical competence of residents. Gonnella, J.S., Veloski, J.J. N. Engl. J. Med. (1982) [Pubmed]
  11. Does masking author identity improve peer review quality? A randomized controlled trial. PEER Investigators. Justice, A.C., Cho, M.K., Winker, M.A., Berlin, J.A., Rennie, D. JAMA (1998) [Pubmed]
  12. Total parenteral nutrition in obstetrics. Seifer, D.B., Silberman, H., Catanzarite, V.A., Conteas, C.N., Wood, R., Ueland, K. JAMA (1985) [Pubmed]
  13. Ephedrine and postoperative hyperamylasaemia in obstetrics. Minakami, H., Koike, T., Sugimura, M., Watanabe, T., Tamada, T. Lancet (1993) [Pubmed]
  14. Human kallikrein 8, a novel biomarker for ovarian carcinoma. Kishi, T., Grass, L., Soosaipillai, A., Scorilas, A., Harbeck, N., Schmalfeldt, B., Dorn, J., Mysliwiec, M., Schmitt, M., Diamandis, E.P. Cancer Res. (2003) [Pubmed]
  15. Paclitaxel plus carboplatin in the treatment of ovarian cancer. ten Bokkel Huinink, W., Veenhof, C., Helmerhorst, T., Bierhorst, F., Dalesio, O., Winograd, B., Depauw, L., Pinedo, H.M. Semin. Oncol. (1995) [Pubmed]
  16. Nosocomial outbreak of Klebsiella pneumoniae producing SHV-5 extended-spectrum beta-lactamase, originating from a contaminated ultrasonography coupling gel. Gaillot, O., Maruéjouls, C., Abachin, E., Lecuru, F., Arlet, G., Simonet, M., Berche, P. J. Clin. Microbiol. (1998) [Pubmed]
  17. Verapamil: placental transfer and effects on maternal and fetal hemodynamics and atrioventricular conduction in the pregnant ewe. Murad, S.H., Tabsh, K.M., Conklin, K.A., Shilyanski, G., Ziadlourad, F., Kapur, P.A., Flacke, W.E. Anesthesiology (1985) [Pubmed]
  18. Binding of human secretory leukocyte protease inhibitor in uterine cervical mucus to immunoglobulins: pathophysiology in immunologic infertility and local immune defense. Hirano, M., Kamada, M., Maegawa, M., Gima, H., Aono, T. Fertil. Steril. (1999) [Pubmed]
  19. Endometrial changes in postmenopausal women treated with tamoxifen for breast cancer. Cohen, I., Rosen, D.J., Shapira, J., Cordoba, M., Gilboa, S., Altaras, M.M., Yigael, D., Beyth, Y. British journal of obstetrics and gynaecology. (1993) [Pubmed]
  20. Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer. Fredstorp-Lidebring, M., Bendahl, P.O., Brünner, N., Casslén, B., Högberg, T., Långström-Einarsson, E., Willén, R., Fernö, M. Eur. J. Cancer (2001) [Pubmed]
  21. Effects of methyldopa on uteroplacental and fetal hemodynamics in pregnancy-induced hypertension. Montan, S., Anandakumar, C., Arulkumaran, S., Ingemarsson, I., Ratnam, S.S. Am. J. Obstet. Gynecol. (1993) [Pubmed]
  22. Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. Porcu, E., Fabbri, R., Seracchioli, R., Ciotti, P.M., Magrini, O., Flamigni, C. Fertil. Steril. (1997) [Pubmed]
  23. Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium. Nakamura, Y., Ono, M., Yoshida, Y., Sugino, N., Ueda, K., Kato, H. Fertil. Steril. (1997) [Pubmed]
  24. Localization of interferon regulatory factor-1 in human endometrium throughout the menstrual cycle. Kitaya, K., Yasuda, J., Fushiki, S., Honjo, H. Fertil. Steril. (2001) [Pubmed]
  25. Perinatal treatment with glucocorticoids and the risk of maldevelopment of the brain. Benesová, O., Pavlík, A. Neuropharmacology (1989) [Pubmed]
  26. Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. Yamano, S., Yamazaki, J., Irahara, M., Tokumura, A., Nakagawa, K., Saito, H. Fertil. Steril. (2004) [Pubmed]
  27. Mother-to-child transmission of human T-cell leukemia virus type-I. Hino, S., Yamaguchi, K., Katamine, S., Sugiyama, H., Amagasaki, T., Kinoshita, K., Yoshida, Y., Doi, H., Tsuji, Y., Miyamoto, T. Jpn. J. Cancer Res. (1985) [Pubmed]
  28. Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845. Longo, L.D. Am. J. Obstet. Gynecol. (1979) [Pubmed]
  29. Pap smear examinations in women post-treated for genital organ diseases by operation and radiation. Pairwuti, S. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (1990) [Pubmed]
  30. Crack/cocaine abusers in the general hospital: assessment and initiation of care. Galanter, M., Egelko, S., De Leon, G., Rohrs, C., Franco, H. The American journal of psychiatry. (1992) [Pubmed]
  31. Levobupivacaine. McClellan, K.J., Spencer, C.M. Drugs (1998) [Pubmed]
  32. Tamoxifen-induced uterine abnormalities: the role of imaging. Ascher, S.M., Imaoka, I., Lage, J.M. Radiology. (2000) [Pubmed]
  33. The efficacy of 1.5% lidocaine with 7.5% dextrose and epinephrine as an epidural test dose for obstetrics. Abraham, R.A., Harris, A.P., Maxwell, L.G., Kaplow, S. Anesthesiology (1986) [Pubmed]
  34. More about d-tubocurarine and succinylcholine in obstetrics. Sellers, W.F., Goddard, R.H. Anesthesiology (1984) [Pubmed]
  35. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. Raspollini, M.R., Amunni, G., Villanucci, A., Boddi, V., Baroni, G., Taddei, A., Taddei, G.L. Gynecol. Oncol. (2004) [Pubmed]
  36. Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women. Richards, E.R., Devine, P.L., Quin, R.J., Fontenot, J.D., Ward, B.G., McGuckin, M.A. Cancer Immunol. Immunother. (1998) [Pubmed]
  37. Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth. Lee, J.S., Choi, Y.D., Choi, C., Lee, M.C., Park, C.S., Min, K.W. Anal. Quant. Cytol. Histol. (2005) [Pubmed]
  38. Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix. Mayer, A., Höckel, M., Vaupel, P. Clin. Cancer Res. (2005) [Pubmed]
  39. Association of E-cadherin and beta-catenin immunoexpression with clinicopathologic features in primary ovarian carcinomas. Faleiro-Rodrigues, C., Macedo-Pinto, I., Pereira, D., Ferreira, V.M., Lopes, C.S. Hum. Pathol. (2004) [Pubmed]
  40. Epidural clonidine analgesia in obstetrics: sheep studies. Eisenach, J.C., Castro, M.I., Dewan, D.M., Rose, J.C. Anesthesiology (1989) [Pubmed]
  41. Maternally administered esmolol produces fetal beta-adrenergic blockade and hypoxemia in sheep. Eisenach, J.C., Castro, M.I. Anesthesiology (1989) [Pubmed]
  42. Pathologic response and toxicity assessment of chemoradiotherapy with cisplatin versus cisplatin plus gemcitabine in cervical cancer: a randomized Phase II study. Dueñas-González, A., Cetina-Perez, L., Lopez-Graniel, C., Gonzalez-Enciso, A., Gómez-Gonzalez, E., Rivera-Rubi, L., Montalvo-Esquivel, G., Muñoz-Gonzalez, D., Robles-Flores, J., Vazquez-Govea, E., de La Garza, J., Mohar, A. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  43. A new approach for the detection of cervical cancer in Thai women. Sindhuphak, R., Issaravanich, S., Udomprasertgul, V., Srisookho, P., Warakamin, S., Sindhuphak, S., Boonbundarlchai, R., Dusitsin, N. Gynecol. Oncol. (2003) [Pubmed]
  44. Hemodynamic effects of intravenous isoproterenol versus saline in the parturient. Marcus, M.A., Vertommen, J.D., Van Aken, H., Wouters, P.F., Van Assche, A., Spitz, B. Anesth. Analg. (1997) [Pubmed]
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